PMID: 7527651Jul 1, 1994Paper

Development of acute myeloblastic leukaemia in a case of aplastic anaemia treated with granulocyte colony-stimulating factor

British Journal of Haematology
T IzumiY Miura

Abstract

We report a case of aplastic anaemia (AA) treated with granulocyte colony-stimulating factor (G-CSF) terminating as acute myeloblastic leukaemia (AML). Because of severe pneumonia, 250 micrograms of G-CSF was administered for 30 d to promote neutrophil recovery. Following G-CSF therapy, myeoblasts appeared, and the diagnosis of AML was then made. The myeloblasts proliferated in response to G-CSF in vitro and in vivo. In AA, development of AML after treatment with G-CSF is rare. Therefore a careful observation for leukaemic transformation is necessary in long-term administration of G-CSF for AA.

Citations

Dec 20, 1995·Toxicology·T Vial, J Descotes
Feb 13, 2013·Journal of the American Academy of Dermatology·May P ChanRosalynn M Nazarian

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