Development of adaptive immunity in rainbow trout, Oncorhynchus mykiss (Walbaum) surviving an infection with Yersinia ruckeri

Fish & Shellfish Immunology
Martin K Raida, K Buchmann

Abstract

Development of adaptive immunity in rainbow trout (Oncorhynchus mykiss) surviving a primary infection with 5x10(5)CFU Yersinia ruckeri O1 (LD(50) dose) was investigated by transcriptome analysis of spleen tissue. These fish surviving a primary infection showed also a significantly increased survival following a secondary infection (same dose) when compared to naïve trout. The weight of the rainbow trout spleen doubled during the first 14 days of the primary infection but the affected organs subsequently recovered normal weight which remained constant during the re-infection period. Gene transcription in the spleen was measured using Quantitative real-time RT-PCR (qPCR). Samples taken 8h.p.i., 1, 3, 7, 14 and 28 d.p.i. were compared to PBS-injected control fish sampled at the same time points. The investigated cytokines and chemokines comprised interleukin (IL)-1beta, IL-1 receptor antagonist (Ra), IL-6, IL-8, IL-10, IL-11 and IFN-gamma, IL-1 receptor I and II (IL-RI and IL-RII). Transcript levels of genes encoding cytokines and receptors were increased during the primary infection but not during the secondary infection. Changes of T cell occurrence or activity in the spleen during the infections were inferred from the transcrip...Continue Reading

Citations

Jun 19, 2013·Veterinary Immunology and Immunopathology·Zhihui ZhangYuanxing Zhang
Sep 7, 2014·Fish & Shellfish Immunology·Sebastián Reyes-CerpaMónica Imarai
Jul 20, 2011·Fish & Shellfish Immunology·Martha Reyes-BecerrilMaría Ángeles Esteban
Apr 7, 2011·Fish & Shellfish Immunology·Yong-An ZhangJ Oriol Sunyer
Jun 23, 2009·Fish & Shellfish Immunology·P Díaz-RosalesC J Secombes
Mar 26, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Christopher Marlowe A CaipangViswanath Kiron
Apr 20, 2012·Molecular Ecology·Camille BonneaudGeoffrey E Hill
Mar 25, 2014·Fish & Shellfish Immunology·A Quesada-GarcíaJ M Navas
Oct 5, 2014·Fish & Shellfish Immunology·Kasper Rømer VillumsenMartin Kristian Raida

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