Development of additional pituitary hormone deficiencies in pediatric patients originally diagnosed with isolated growth hormone deficiency due to organic causes

European Journal of Endocrinology
Christopher J ChildRon G Rosenfeld

Abstract

To determine characteristics of children initially diagnosed with isolated growth hormone deficiency (IGHD) of organic aetiology, who later developed multiple pituitary hormone deficiencies (MPHD). Data were analysed for 716 growth hormone-treated children with organic IGHD, who were growth hormone-naïve at baseline in the multinational, observational Genetics and Neuroendocrinology of Short Stature International Study. Development of MPHD was ascertained from investigator-provided diagnoses, adverse events and concomitant medications. Analyses were performed for all patients and separately for those who developed MPHD within 4.5 years or had >3.5 years follow-up and continued to have IGHD (4-year cohort). MPHD developed in 71/716 (9.9%) children overall, and in 60/290 (20.7%) in the 4-year cohort. The most frequent additional deficiencies were thyroid-stimulating hormone (47 patients) and gonadotropins (23 patients). Compared with those who remained with IGHD, children who developed MPHD had more severe GHD at study entry, significantly lower baseline insulin-like growth factor1, peak stimulated growth hormone, and more frequent diagnosis of intracranial tumour or mutation of gene(s) controlling hypothalamic-pituitary developm...Continue Reading

References

Jul 1, 1992·Baillière's Clinical Endocrinology and Metabolism·J R Bierich
Oct 7, 2000·European Journal of Endocrinology·M BozzolaJ L Chaussain
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Martin LangeJørn Müller
Oct 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Emily C WalvoordErica A Eugster
Feb 24, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·R CoyaUNKNOWN GEDPIT group
Mar 4, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen J LaughtonAmar Gajjar
Mar 13, 2008·The Journal of Clinical Endocrinology and Metabolism·Adda GrimbergMichael P Wajnrajch
Mar 19, 2009·Endocrine Development·Ken H Darzy, Stephen M Shalet
Mar 27, 2009·Clinical Endocrinology·Ameeta MehtaMehul T Dattani
May 12, 2010·Clinical Endocrinology·Lucy Ann BehanAmar Agha
Mar 15, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·J M WitP Mullis
Mar 15, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·R Pfäffle, J Klammt
Apr 24, 2012·Annales d'endocrinologie·Frédéric CastinettiThierry Brue
Jan 24, 2014·Endocrine Reviews·Kyriaki S AlatzoglouMehul T Dattani
Jan 7, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wassim ChemaitillyCharles A Sklar
Jun 10, 2015·Scientific Reports·Adda GrimbergVirginia A Stallings

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Citations

Jul 10, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Monika Prokop-PiotrkowskaMieczysław Szalecki
Nov 8, 2018·Endocrine Connections·Laura van IerselHanneke Margo van Santen
May 9, 2019·Journal of the Endocrine Society·Stephen ZborovskiJennifer Harrington
Jul 9, 2016·Current Opinion in Pediatrics·Antonis VoutetakisCatherine Dacou-Voutetakis

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