PMID: 3746656Sep 1, 1986Paper

Development of adrenergic and nonadrenergic pressor mechanisms in rats sympathectomized from birth

The Journal of Pharmacology and Experimental Therapeutics
E MillsP G Smith

Abstract

Rats were sympathectomized by administering guanethidine from birth through 50 days of age. Experiments were performed in vivo under anesthesia at 18, 25, 40, 60, 70 and 100 days of age to determine if sympathectomy (SNX) attenuated development of vascular noradrenergic contraction and the mechanisms that support mean arterial blood pressure (MAP) after SNX. The maximum and ED50 of the pressor response to the alpha-1 noradrenergic agonist methoxamine was used to test contractility. MAP support mechanisms were assessed indirectly by measuring hypotensive responses to sequential interventions: adrenalectomy, chlorisondamine (ganglionic blockade), phentolamine (alpha-1 and alpha-2 noradrenergic blockade), angiotensin II antagonist, arginine vasopressin antagonist and hydralazine (direct acting vasodilator). Guanethidine abolished the pressor response to tyramine-evoked norepinephrine release, decreased plasma norepinephrine 70% without change in epinephrine and decreased methoxamine ED50. Maxima of methoxamine pressor responses were comparable in sympathectomized rats and controls at all ages. Resting MAP was 7 to 20% lower in sympathectomized rats, but MAP after eliminating autonomic nerve influences was 27 to 36% higher. SNX abo...Continue Reading

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.