PMID: 25764486DOI: 10.3390/molecules20034430Mar 13, 2015Paper
Development of advanced macrosphelides: potent anticancer agents
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Seung-Mann Paek
Abstract
Synthetic approaches to macrosphelide derivatives, based on medicinal chemistry, are summarized. This review contains conventional medicinal chemistry approaches, combinatorial chemistry, fluorous tagging techniques and affinity chromatography preparation. In addition, advances in their apoptosis-inducing activities are also included.
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Citations
Jun 1, 2018·Chemistry & Biodiversity·Gastón E SilessGabriela M Cabrera
Jul 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarzyna WińskaMirosław Anioł
May 21, 2018·Journal of Natural Medicines·Satoshi Takamatsu
Aug 30, 2019·Marine Drugs·Min Woo HaSeung-Mann Paek
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Methods Mentioned
BETA
X-ray
amidation
flow cytometry
Related Concepts
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Apoptosis
Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis
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Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
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