Development of an acid ceramidase activity-based probe

Chemical Communications : Chem Comm
Cécile M J OuairyHerman S Overkleeft

Abstract

Acid ceramidase is responsible for the ultimate step in the catabolism of (glyco)sphingolipids by hydrolysis of ceramide into sphingosine and free fatty acid. Deficiency in acid ceramidase is the molecular basis of Farber disease. Here we report the synthesis and characterization of an activity-based acid ceramidase probe.

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Citations

Dec 15, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Debojit Bhattacherjee, Krishna Pada Bhabak
Jul 30, 2015·Chemistry and Physics of Lipids·Essa M Saied, Christoph Arenz
Jun 24, 2015·ACS Chemical Biology·Elisa RomeoDaniele Piomelli
Sep 1, 2017·Future Medicinal Chemistry·Christoph Arenz
Aug 19, 2020·Essays in Biochemistry·Marco van EijkJohannes M F G Aerts
Jun 28, 2018·ACS Omega·Sagar S ThoratRavindar Kontham
Apr 30, 2019·Journal of the American Chemical Society·Yadira F OrdóñezGemma Fabrias

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