Development of an adaptive pulmonary simulator for in vitro analysis of patient populations and patient-specific data

Computer Methods and Programs in Biomedicine
Jacob M KingCharles E Taylor

Abstract

Patient-specific modeling (PSM) is gaining more attention from researchers due to its ability to potentially improve diagnostic capabilities, guide the design of intervention procedures, and optimize clinical management by predicting the outcome of a particular treatment and/or surgical intervention. Due to the hemodynamic diversity of specific patients, an adaptive pulmonary simulator (PS) would be essential for analyzing the possible impact of external factors on the safety, performance, and reliability of a cardiac assist device within a mock circulatory system (MCS). In order to accurately and precisely replicate the conditions within the pulmonary system, a PS should not only account for the ability of the pulmonary system to supply blood flow at specific pressures, but similarly consider systemic outflow dynamics. This would provide an accurate pressure and flow rate return supply back into the left ventricular section of the MCS (i.e. the initial conditions of the left heart). Employing an embedded Windkessel model, a control system model was developed utilizing MathWorks' Simulink® Simscape™. Following a verification and validation (V&V) analysis approach, a PI-controlled closed-loop hydraulic system was developed using...Continue Reading

Citations

Feb 1, 2019·Biomedical Engineering Online·Jacob M KingCharles E Taylor
Nov 26, 2019·Computer Methods and Programs in Biomedicine·Xin MaYouqing Wang
Sep 29, 2021·The International Journal of Artificial Organs·Femke CapponAshraf W Khir

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