Development of an algorithm to identify pregnancy episodes and related outcomes in health care claims databases: An application to antiepileptic drug use in 4.9 million pregnant women in France

Pharmacoepidemiology and Drug Safety
Pierre-Olivier BlotièreFrançois Alla

Abstract

Access to claims databases provides an opportunity to study medication use and safety during pregnancy. We developed an algorithm to identify pregnancy episodes in the French health care databases and applied it to study antiepileptic drug (AED) use during pregnancy between 2007 and 2014. The algorithm searched the French health care databases for discharge diagnoses and medical procedures indicative of completion of a pregnancy. To differentiate claims associated with separate pregnancies, an interval of at least 28 weeks was required between 2 consecutive pregnancies resulting in a birth and 6 weeks for terminations of pregnancy. Pregnancy outcomes were categorized into live births, stillbirths, elective abortions, therapeutic abortions, spontaneous abortions, and ectopic pregnancies. Outcome dates and gestational ages were used to calculate pregnancy start dates. According to our algorithm, live birth was the most common pregnancy outcome (73.9%), followed by elective abortion (17.2%), spontaneous abortion (4.2%), ectopic pregnancy (1.1%), therapeutic abortion (1.0%), and stillbirth (0.4%). These results were globally consistent with French official data. Among 7 559 701 pregnancies starting between 2007 and 2014, correspond...Continue Reading

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Citations

Nov 22, 2019·Pharmacoepidemiology and Drug Safety·Sara Sanchez OrtizLucía Cea Soriano
Jun 14, 2019·Neurology·Pierre-Olivier BlotièreRosemary Dray-Spira
Oct 16, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Charles DeCarloAnahita Dua
Feb 25, 2019·Thérapie·Justine BeneventChristine Damase-Michel
Aug 20, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Hélène TillautEmmanuelle Leray
Oct 1, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Keran MollSteven Anderson
Oct 7, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Pierre-Olivier BlotièreGéric Maura
Sep 29, 2020·Neurology. Clinical Practice·Astrid Barataud-ReilhacEmmanuelle Leray

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Methods Mentioned

BETA
medical procedure

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