Development of an Evidence biochip array kit for the multiplex screening of more than 20 anthelmintic drugs

Analytical and Bioanalytical Chemistry
J PorterS Pete Fitzgerald

Abstract

Anthelmintic drugs are used in clinical and veterinary practice for the treatment of infections caused by parasitic worms. Their extensive use in food-producing animals can cause the presence of residues in food. For consumer protection it is necessary to monitor the levels of anthelmintic residues to ensure that they remain within the legally permitted maximum acceptable concentrations. For this purpose, the use of multiplex screening methods is advantageous. Biochip array technology allows the simultaneous determination of multiple analytes from a single sample at a single point in time. This study reports the development of an Evidence biochip array for the multiplex screening of anthelmintic drugs. Simultaneous competitive chemiluminescent immunoassays are employed. The solid support and vessel is the biochip, which contains an array of discrete test sites. The assays were applied to the semiautomated bench-top analyser Evidence Investigator. The aminobenzimidazoles assay detected aminomebendazole, albendazole 2-aminosulphone and aminoflubendazole, the avermectins assay detected emamectin benzoate, eprinomectin, abamectin, ivermectin and doramectin, the benzimidazoles assay detected albendazole sulphone, albendazole, albend...Continue Reading

References

Oct 3, 2002·Journal of Agricultural and Food Chemistry·David L BrandonSteven A Barker
May 14, 2005·Clinical Chemistry·Stephen P FitzgeraldEl O Benchikh
Nov 29, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Roisin M MolloyStephen P FitzGerald
Aug 26, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Martin DanaherMichael O'Keeffe
Sep 5, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Martin DanaherMichael O'Keeffe

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Citations

Jul 9, 2014·Analytical and Bioanalytical Chemistry·Michael Seidel, Reinhard Niessner
Nov 16, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Jennifer L Shea

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Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.