Development of an Experimental Model for Analyzing Drug Resistance in Colorectal Cancer

Cancers
Mohamed ElbadawyKazuaki Sasaki

Abstract

Colorectal cancer (CRC) is one of the most common cancers, for which combination treatment of chemotherapy is employed. However, most patients develop drug resistance during the course of treatment. To clarify the mechanisms of drug resistance, various research models have been developed. Recently, we established a human CRC patients-derived three-dimensional (3D) culture system using an air-liquid interface organoid method. It contained numerous cancer stem cells and showed resistance to 5-fluorouracil and Irinotecan. In this review, we introduce conventional and our established models for studying drug resistance in CRC.

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Citations

Jun 4, 2020·Cancers·George M RamzyPatrycja Nowak-Sliwinska
Aug 14, 2019·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Tatsuya Usui, Kazuaki Sasaki
Jun 12, 2020·Scientific Reports·Amira AbugomaaKazuaki Sasaki
May 27, 2021·Cancer Biology & Therapy·Mohamed ElbadawyKazuaki Sasaki
Aug 7, 2021·Environmental Science and Pollution Research International·Ahmed ElfadadnyMohamed Elbadawy
Aug 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohamed ElbadawyKazuaki Sasaki

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