Development of an image-based network model of retinal vasculature

Annals of Biomedical Engineering
P GanesanHeping Xu

Abstract

The paper presents an image-based network model of retinal vasculature taking account of the 3D vascular distribution of the retina. Mouse retinas were prepared using flat-mount technique and vascular images were obtained using confocal microscopy. The vascular morphometric information obtained from confocal images was used for the model development. The network model developed directly represents the vascular geometry of all the large vessels of the arteriolar and venular trees and models the capillaries using uniformly distributed meshes. The vasculatures in different layers of the retina, namely the superficial, intermediate, and deep layer, were modeled separately in the network and were linked through connecting vessels. The branching data of the vasculatures was recorded using the method of connectivity matrix of network (the graph theory). Such an approach is able to take into account the detailed vasculature of individual retinas concerned. Using the network model developed, a circulation analysis based on Poiseuille's equation was carried out. The investigations produced predictions of spatial distribution of the pressure, flow, and wall shear stress in the entire retinal vasculature. The method developed can be used a...Continue Reading

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Citations

Feb 12, 2013·Bioinformatics·Brian E RuttenbergAmbuj K Singh
Feb 11, 2014·Mathematical Biosciences and Engineering : MBE·Giovanna GuidoboniBrent A Siesky
Aug 1, 2014·Journal of the Royal Society, Interface·Miguel O BernabeuPeter V Coveney
Feb 1, 2011·Computer Methods and Programs in Biomedicine·P GanesanH Xu
Nov 4, 2010·Medical Engineering & Physics·P GanesanH Xu
Apr 12, 2016·Progress in Retinal and Eye Research·Paul A RobertsHelen M Byrne
Feb 18, 2015·Bioinformatics·Aruna JammalamadakaGabriel Luna
Nov 6, 2013·Journal of Biomechanical Engineering·Qing PanGangmin Ning
Feb 9, 2017·Bulletin of Mathematical Biology·Nathaniel J KarstRussell T Carr
Nov 13, 2020·Frontiers in Physiology·Ricardo SantamaríaAlicia G Arroyo

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