Development of an in vivo swine model of biliary dilatation-based direct peroralcholangioscopy

Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society
Jin-Seok ParkDon Haeng Lee

Abstract

A reproducible in vivo swine model of bile duct dilation (BDD) was recently established and reported for the preclinical testing of newly developed biliary devices or endoscopic techniques. The aim of this study is to develop more advanced large animal model which is possible to direct examination of the biliary tree. Six mini pigs were prepared for the study. The BDD models were first made by closure of the ampulla of Vater in all swine. Then endoscopic papillary balloon dilation (EPBD) was performed in the animals. The feasibility of single-operator peroralcholangioscopy without assistance of accessories was evaluated using an ultra-slim upper endoscope in the animals. EPBD could be implemented using a dilation balloon catheter (10 ~ 13.5 mm) in all BDD models (6/6, 100%). The success rate of free-hand direct insertion of an ultra-slim endoscope into the common bile duct (CBD) was 100% (6/6), and access to the common hepatic duct with examination was possible using the direct peroralcholangioscopy in five animals (5/6, 83.3%). None of the animals died. In the cholangioscopic examination, a bile duct polyp and a benign biliary stricture occurred naturally, respectively, in two of six swine. An in vivo swine model of biliary di...Continue Reading

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Citations

Nov 28, 2017·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Mariano Eduardo GimenezJacques Marescaux
Sep 30, 2020·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Mariano Eduardo GiménezJacques Marescaux
Jul 28, 2019·BMC Gastroenterology·Jun-Jie YangTian-Rang Liu
Dec 16, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Chang-Il KwonDon Haeng Lee
Mar 25, 2021·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Seok JeongDon Haeng Lee

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