Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2

Hui WangXiaoming Yang


The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) threatens global public health. The development of a vaccine is urgently needed for the prevention and control of COVID-19. Here, we report the pilot-scale production of an inactivated SARS-CoV-2 vaccine candidate (BBIBP-CorV) that induces high levels of neutralizing antibodies titers in mice, rats, guinea pigs, rabbits, and nonhuman primates (cynomolgus monkeys and rhesus macaques) to provide protection against SARS-CoV-2. Two-dose immunizations using 2 μg/dose of BBIBP-CorV provided highly efficient protection against SARS-CoV-2 intratracheal challenge in rhesus macaques, without detectable antibody-dependent enhancement of infection. In addition, BBIBP-CorV exhibits efficient productivity and good genetic stability for vaccine manufacture. These results support the further evaluation of BBIBP-CorV in a clinical trial.


Jul 24, 2002·Nucleic Acids Research·Kazutaka KatohTakashi Miyata
Jan 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Zhi-yong YangGary J Nabel
Mar 13, 2010·PloS One·Morgan N PriceAdam P Arkin
Apr 23, 2016·Human Vaccines & Immunotherapeutics·Chao Zhang, Dongming Zhou
May 14, 2016·World Journal of Virology·Muthannan Andavar Ramakrishnan
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Jan 28, 2020·Lancet·Chen WangGeorge F Gao
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Feb 12, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Peter L Stern
Apr 1, 2020·The New England Journal of Medicine·Nicole LurieJane Halton
Apr 8, 2020·Current Opinion in Immunology·Ebony N Gary, David B Weiner
Apr 23, 2020·Animal Models and Experimental Medicine·Pin YuChuan Qin
May 13, 2020·Nature·Vincent J MunsterEmmie de Wit
May 22, 2020·Science·Jingyou YuDan H Barouch

❮ Previous
Next ❯


Jun 28, 2020·Journal of Virology·John P Moore, P J Klasse
Aug 18, 2020·Transboundary and Emerging Diseases·Guangzhi ZhangShangjin Cui
Sep 8, 2020·Environmental Microbiology·Harald Brüssow
Aug 25, 2020·Journal of Medical Virology·Ji-Ming Chen
Sep 25, 2020·Current Opinion in HIV and AIDS·Yihan WangDongming Zhou
Sep 24, 2020·Nature·Florian Krammer
Sep 6, 2020·Nature Reviews. Immunology·Mangalakumari JeyanathanZhou Xing
Aug 21, 2020·Signal Transduction and Targeted Therapy·Shuaiyao LuXiaozhong Peng
Oct 13, 2020·Frontiers in Microbiology·Yuki Furuse, Hitoshi Oshitani
Oct 18, 2020·Nature Reviews. Microbiology·Shan SuShibo Jiang
Oct 15, 2020·Signal Transduction and Targeted Therapy·Yetian DongFangfang Zhou
Nov 4, 2020·Future Microbiology·Kenneth Lundstrom
Nov 29, 2020·Signal Transduction and Targeted Therapy·Zezhong LiuShibo Jiang
Dec 4, 2020·Human Vaccines & Immunotherapeutics·Vipin M Vashishtha, Puneet Kumar
Dec 23, 2020·Viral Immunology·Minghao DongYu Deng
Dec 29, 2020·Advanced Drug Delivery Reviews·Jee Young ChungYoung Jik Kwon
Dec 9, 2020·British Journal of Clinical Pharmacology·Ester Calvo Fernández, Lucie Y Zhu
Jan 14, 2021·Journal of Biomedical Science·Ioannis P TrougakosMeletios A Dimopoulos
Dec 5, 2020·Nature·Katherine McMahanDan H Barouch
Jan 12, 2021·The Journal of Biological Chemistry·Sameer Kumar MalladiRaghavan Varadarajan
Jan 27, 2021·Cells·Rameswari Chilamakuri, Saurabh Agarwal
Jan 12, 2021·Biomicrofluidics·Jinming YuChenjie Xu
Dec 2, 2020·Nature·Lorena Sanchez-FelipeKai Dallmeier
Dec 20, 2020·Nature Reviews. Immunology·Lianpan Dai, George F Gao
Nov 27, 2020·Frontiers in Immunology·Zhihui LiangBingbing Sun
Dec 29, 2020·Frontiers in Immunology·Gisela Canedo-MarroquínAlexis M Kalergis
Feb 12, 2021·International Journal of Environmental Research and Public Health·Iqra MehmoodMuhammad Tahir Ul Qamar
Oct 31, 2020·Frontiers in Immunology·Katie L FlanaganSophie Ch Wen
Nov 3, 2020·Clinical and Translational Medicine·Jiansheng HuangYoufa Wang
Jan 23, 2021·Advanced Drug Delivery Reviews·Saborni ChakrabortyTaia T Wang
Jan 25, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wagner Gouvêa Dos Santos
Dec 3, 2020·Canadian Journal of Microbiology·Raquel L RussellBrian L Mark
Jan 7, 2021·Military Medical Research·Dan-Dan Li, Qi-Han Li
Feb 4, 2021·Signal Transduction and Targeted Therapy·Pengfei JinFengcai Zhu
Oct 31, 2020·Human Vaccines & Immunotherapeutics·Lifeng LiHuiqing Sun
Nov 10, 2020·Frontiers in Immunology·Omna SharmaChris R Triggle
Dec 21, 2020·Journal of Biomedical Science·Yen-Der LiT-C Wu

❮ Previous
Next ❯

Methods Mentioned

bronchoalveolar lavage
electron microscopy
genetic modification
flow cytometry

Software Mentioned

Biosystems 7500

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.