Development of an integrated multimodal optical imaging system with real-time image analysis for the evaluation of oral premalignant lesions

Journal of Biomedical Optics
Eric C YangRebecca Richards-Kortum

Abstract

Oral premalignant lesions (OPLs), such as leukoplakia, are at risk of malignant transformation to oral cancer. Clinicians can elect to biopsy OPLs and assess them for dysplasia, a marker of increased risk. However, it is challenging to decide which OPLs need a biopsy and to select a biopsy site. We developed a multimodal optical imaging system (MMIS) that fully integrates the acquisition, display, and analysis of macroscopic white-light (WL), autofluorescence (AF), and high-resolution microendoscopy (HRME) images to noninvasively evaluate OPLs. WL and AF images identify suspicious regions with high sensitivity, which are explored at higher resolution with the HRME to improve specificity. Key features include a heat map that delineates suspicious regions according to AF images, and real-time image analysis algorithms that predict pathologic diagnosis at imaged sites. Representative examples from ongoing studies of the MMIS demonstrate its ability to identify high-grade dysplasia in OPLs that are not clinically suspicious, and to avoid unnecessary biopsies of benign OPLs that are clinically suspicious. The MMIS successfully integrates optical imaging approaches (WL, AF, and HRME) at multiple scales for the noninvasive evaluation ...Continue Reading

References

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Jun 15, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Jang-Jaer LeeSang-Heng Kok
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Mar 5, 2009·Journal of Biomedical Optics·Ina PavlovaRebecca Richards-Kortum
Apr 30, 2009·Cancer Prevention Research·Darren RoblyerRebecca Richards-Kortum
Dec 10, 2007·Optics Express·Timothy J MuldoonRebecca Richards-Kortum
May 4, 2012·Cancer Prevention Research·Mark C PierceAnn M Gillenwater
Jun 16, 2018·Cancer Prevention Research·Eric C YangRebecca R Richards-Kortum

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Methods Mentioned

BETA
biopsy
biopsies
light scattering
surgical resection

Software Mentioned

Python
HRME
Arduino
MMIS

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