Abstract
Interstitial cystitis/bladder pain syndrome (IC) is a multifactorial syndrome of severe pelvic and genitalia pain and compromised urinary function; a subset of IC patients present with Hunner's lesions or ulcers on their bladder walls (UIC). UIC is diagnosed by cystoscopy, which may be quite painful. The objective of this study was to determine if a calculated Bladder Permeability Defect Risk Score (BP-RS) based on non-invasive urinary cytokines could discriminate UIC patients from controls and IC patients without Hunner's ulcers. A national crowdsourcing effort targeted IC patients and age-matched controls to provide urine samples. Urinary cytokine levels for GRO, IL-6, and IL-8 were determined using a Luminex assay. We collected 448 urine samples from 46 states consisting of 153 IC patients (147 female, 6 male), of which 54 UIC patients (50 females, 4 male), 159 female controls, and 136 male controls. A defined BP-RS was calculated to classify UIC, or a bladder permeability defect etiology, with 89% validity. The BP-RS Score quantifies UIC risk, indicative of a bladder permeability defect etiology in a subset of IC patients. The Bladder Permeability Defect Risk Score is the first validated urine biomarker assay for interstiti...Continue Reading
References
Sep 1, 1992·The Journal of Urology·T SeguchiA Okuyama
Sep 1, 1994·The Journal of Urology·M LotzB L Zuraw
May 1, 1997·The Journal of Urology·R DavidoffP M Lad
Sep 1, 1997·The Journal of Urology·D R EricksonD J Dabbs
Dec 4, 1998·Urology·S KeayJ W Warren
May 30, 2001·Urology·S K KeayT Chai
May 7, 2002·The Journal of Urology·Deborah R EricksonSusan K Keay
Apr 4, 2003·Biotechnology and Bioengineering·Enhong CaoPeter R Foster
Aug 18, 2004·The Journal of Urology·Masahiro TamakiTomohiro Ueda
May 3, 2005·BMC Urology·Chen-Ou ZhangChui-Ze Kong
Aug 18, 2005·British Journal of Cancer·L M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Jan 10, 2006·BMC Bioinformatics·Ramón Díaz-Uriarte, Sara Alvarez de Andrés
Oct 31, 2006·Urology·Leah M LamaleKarl J Kreder
Aug 23, 2007·Journal of the American Medical Informatics Association : JAMIA·Florence T BourgeoisKenneth D Mandl
Jan 26, 2010·The Journal of Urology·Teruyuki OgawaOsamu Nishizawa
Jun 21, 2011·The Journal of Urology·Sandra H BerryJ Quentin Clemens
Apr 17, 2012·The Journal of Urology·Pradeep TyagiKenneth M Peters
Nov 21, 2012·The Journal of Urology·Anne M SuskindJ Quentin Clemens
May 3, 2013·PloS One·Miao-Fen ChenChun-Te Wu
May 9, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Hann-Chorng Kuo
Aug 3, 2014·BMC Urology·J Quentin ClemensUNKNOWN MAPP Research Network Study Group
Jan 28, 2015·The Journal of Urology·Philip M HannoUNKNOWN American Urological Association
Nov 21, 2015·PloS One·Daichi MaedaYukio Homma
Nov 26, 2015·Drugs·Samuel BelknapDeborah Erickson
Jun 21, 2016·EBioMedicine·Kaveri S ParkerJeffrey P Henderson
Sep 23, 2016·Clinical Journal of the American Society of Nephrology : CJASN·William HerringtonSarah Clark
Citations
Dec 12, 2017·The Journal of Urology·Michael B ChancellorLaura E Lamb
Nov 27, 2018·F1000Research·Pradeep TyagiChristopher Chermansky
Oct 30, 2020·PloS One·Bernadette M M ZwaansLaura E Lamb
Nov 21, 2020·Medical Hypotheses·Laura E LambMichael B Chancellor
Feb 20, 2021·Neurourology and Urodynamics·H Henry LaiUNKNOWN MAPP Research Network
Jan 27, 2022·International Urology and Nephrology·Elijah P WardLaura E Lamb