Development of an interstitial cystitis risk score for bladder permeability

PloS One
Laura E LambMichael B Chancellor

Abstract

Interstitial cystitis/bladder pain syndrome (IC) is a multifactorial syndrome of severe pelvic and genitalia pain and compromised urinary function; a subset of IC patients present with Hunner's lesions or ulcers on their bladder walls (UIC). UIC is diagnosed by cystoscopy, which may be quite painful. The objective of this study was to determine if a calculated Bladder Permeability Defect Risk Score (BP-RS) based on non-invasive urinary cytokines could discriminate UIC patients from controls and IC patients without Hunner's ulcers. A national crowdsourcing effort targeted IC patients and age-matched controls to provide urine samples. Urinary cytokine levels for GRO, IL-6, and IL-8 were determined using a Luminex assay. We collected 448 urine samples from 46 states consisting of 153 IC patients (147 female, 6 male), of which 54 UIC patients (50 females, 4 male), 159 female controls, and 136 male controls. A defined BP-RS was calculated to classify UIC, or a bladder permeability defect etiology, with 89% validity. The BP-RS Score quantifies UIC risk, indicative of a bladder permeability defect etiology in a subset of IC patients. The Bladder Permeability Defect Risk Score is the first validated urine biomarker assay for interstiti...Continue Reading

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Citations

Dec 12, 2017·The Journal of Urology·Michael B ChancellorLaura E Lamb
Nov 27, 2018·F1000Research·Pradeep TyagiChristopher Chermansky
Feb 20, 2021·Neurourology and Urodynamics·H Henry LaiUNKNOWN MAPP Research Network
Jan 27, 2022·International Urology and Nephrology·Elijah P WardLaura E Lamb

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Methods Mentioned

BETA
protein assay
urine collection
urine collect
urine sample collection

Software Mentioned

GraphPad
Learn
Prism
Scikit
MARKer
Python

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