Development of an intrabiliary MR imaging-monitored local agent delivery technique: a feasibility study in pigs.

Radiology
Feng ZhangXiaoming Yang

Abstract

To investigate the feasibility of using magnetic resonance (MR) imaging to monitor intrabiliary delivery of motexafin gadolinium (MGd) into pig common bile duct (CBD) walls. Animal studies were approved by the Institutional Animal Care and Use Committee. Initially, human cholangiocarcinoma cells were treated with various concentrations of MGd, a compound serving as a T1-weighted MR imaging contrast agent, chemotherapy drug, and cell marker. These cells were then examined by means of confocal microscopy to confirm the intracellular uptake of MGd. In addition, an MGd/trypan blue mixture was locally infused into CBD walls of six cadaveric pigs using a microporous balloon catheter. CBDs of six pigs were infused with saline to serve as controls. Ex vivo T1-weighted MR imaging of these CBDs was performed. For in vivo technical validation, the microporous balloon catheter was placed in the CBD by means of a transcholecytic access to deliver MGd/trypan blue into CBD walls of six living pigs. T1-weighted images were obtained with both a surface coil and an intrabiliary MR imaging guidewire, and contrast-to-noise ratios of CBD walls before and after MGd/trypan blue infusions were compared in the two groups by means of paired t test, with...Continue Reading

References

Mar 8, 2003·International Journal of Cardiovascular Interventions·Xiaoming YangElias A Zerhouni
Sep 24, 2004·AJR. American Journal of Roentgenology·Aravind ArepallyDavid A Bluemke
Apr 26, 2007·Clinical Medicine & Research·Gianfranco DonelliAntonio Basoli
Oct 26, 2007·European Radiology·Otto M van Delden, Johan S Laméris
Dec 1, 2007·Journal of Magnetic Resonance Imaging : JMRI·Chris BrushettXiaoming Yang

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Citations

Sep 9, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haonan LiKui Luo

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