Development of an LC-MS/MS method to quantify sex hormones in bovine milk and influence of pregnancy in their levels

Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Patricia RegalCristina Fente

Abstract

Hormones work in harmony in the body, and this status must be maintained to avoid metabolic disequilibrium and the subsequent illness. Besides, it has been reported that exogenous steroids (presence in the environment and food products) influence the development of several important illnesses in humans. Endogenous steroid hormones in food of animal origin are unavoidable as they occur naturally in these products. The presence of hormones in food has been connected with several human health problems. Bovine milk contains considerable quantities of hormones and it is of particular concern. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, based on hydroxylamine derivatisation, has been developed and validated for the quantification of six sex hormones in milk [pregnenolone (P₅), progesterone (P₄), estrone (E₁), testosterone (T), androstenedione (A) and dehydroepiandrosterone (DHEA)]. This method has been applied to real raw milk samples and the existence of differences between milk from pregnant and non-pregnant cows has been statistically confirmed. Basing on a revision of existing published data, it could be concluded that maximum daily intakes for hormones are not reached through milk ingestion. Although dair...Continue Reading

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Citations

May 6, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Yasuhiro ShibataSeijiro Honma
Dec 9, 2015·Reproduction in Domestic Animals = Zuchthygiene·A RotaG Lubas
Aug 19, 2015·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Takayuki NakajimaIchiro Takano
Sep 5, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Xiaoqin HeZhaode Mu
Apr 9, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Alexandre GoyonPascal Mottier
Jan 20, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·R BarreiroA Cepeda
Dec 27, 2017·International Journal of Environmental Research and Public Health·Xueyin QuJiaqi Wang
May 16, 2019·Critical Reviews in Food Science and Nutrition·Hongbin PuHaohua Fu
Jun 15, 2021·Psychoneuroendocrinology·Julia StrojnyBernadette von Dawans

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MDS SCIEX
ResVal (
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