Development of an ovine model of myocardial infarction

ANZ Journal of Surgery
Shahram RabbaniSeyed Mahdi Nassiri

Abstract

We report experimental myocardial infarction by occluding coronary arteries in ovine models. Twelve ewes were included in the study. After the chest was opened by left lateral thoracotomy incision, the second diagonal branch of the left anterior descending coronary artery was ligated at a point approximately 40% distant from its base. Prophylactic anti-arrhythmics were given. Animals were mechanically ventilated during surgery and stayed in intensive care unit for 24 h postoperation. Experiments were then evaluated by echocardiographic, electrocardiographic, haemodynamic, serological and morphological investigations. Echocardiographic measurements were repeated after 2 months and animals were then killed for post-mortem cardiac examinations. All animals survived the surgical procedure. Cyanotic discoloration and hypokinesia in the cardiac tissue in an area of (30 +/- 2) x (4 +/- 2) mm plus ST-segment elevations was detected immediately after vessel ligation. Moreover, there were pathological Q-waves 2 months later. Echocardiographic evaluations showed an average of 30% relative decrease in cardiac ejection fraction. Wall motion analysis showed anteroseptal hypokinesia and akinesia in all animals 1 day and 2 months after operati...Continue Reading

References

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Citations

Dec 25, 2013·BioMed Research International·Tyler SpataAhmet Kilic
Jun 19, 2013·The Journal of Surgical Research·Tieluo LiBartley P Griffith
Sep 29, 2011·The Journal of Gene Medicine·Michael G KatzCharles R Bridges
Nov 22, 2019·Frontiers in Cardiovascular Medicine·Stefan Michael SattlerThomas Jespersen
Jul 10, 2020·Artificial Organs·Carolin TorregrozaDiyar Saeed
May 18, 2021·Frontiers in Bioengineering and Biotechnology·Hye Sook ShinYasuhiro Shudo

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