Development of an ultrasound-responsive and mannose-modified gene carrier for DNA vaccine therapy

Biomaterials
Keita UnMitsuru Hashida

Abstract

Development of a gene delivery system to transfer the gene of interest selectively and efficiently into targeted cells is essential for achievement of sufficient therapeutic effects by gene therapy. Here, we succeeded in developing the gene transfection method using ultrasound (US)-responsive and mannose-modified gene carriers, named Man-PEG(2000) bubble lipoplexes. Compared with the conventional lipofection method using mannose-modified carriers, this transfection method using Man-PEG(2000) bubble lipoplexes and US exposure enabled approximately 500-800-fold higher gene expressions in the antigen presenting cells (APCs) selectively in vivo. This enhanced gene expression was contributed by the improvement of delivering efficiency of nucleic acids to the targeted organs, and by the increase of introducing efficiency of nucleic acids into the cytoplasm followed by US exposure. Moreover, high anti-tumor effects were demonstrated by applying this method to DNA vaccine therapy using ovalbumin (OVA)-expressing plasmid DNA (pDNA). This US-responsive and cell-specific gene delivery system can be widely applied to medical treatments such as vaccine therapy and anti-inflammation therapy, which its targeted cells are APCs, and our finding...Continue Reading

References

May 5, 1999·Lancet·K TachibanaK Tamura
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·N S Potter, C V Harding
Feb 7, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·Saulius SatkauskasLluis M Mir
Jun 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·John WongSamuel S Lee
Feb 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Vladimir P TorchilinGerard G M D'Souza
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Raymond M SchiffelersGert Storm
Jan 13, 2004·Nature Immunology·Eicke LatzDouglas T Golenbock
May 19, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mangesh C DeshpandeSnjezana Stolnik
Jan 5, 2005·Journal of Leukocyte Biology·Joan M Cook-Mills, Tracy L Deem
Jan 26, 2005·Trends in Immunology·Philip R TaylorLuisa Martinez-Pomares
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·John J DonnellyMargaret A Liu
Sep 27, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoshiyuki HattoriMitsuru Hashida
Apr 21, 2006·The Journal of Gene Medicine·Yoshiyuki HattoriMitsuru Hashida
May 4, 2006·The Journal of Pharmacology and Experimental Therapeutics·Yoshiyuki HattoriMitsuru Hashida
Jul 11, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yiyao LiuMichihiro Nakamura
Sep 23, 2006·The Journal of Biological Chemistry·Cynthia A LeiferDavid M Segal
Dec 15, 2006·World Journal of Gastroenterology : WJG·George KoliosElias Kouroumalis
Apr 24, 2007·Nature Immunology·Kang LiuMichel Nussenzweig
Sep 15, 2007·Nature Reviews. Immunology·Paul J TackenCarl G Figdor
Sep 28, 2007·Nature·Ralph M Steinman, Jacques Banchereau
Nov 24, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ryo SuzukiKazuo Maruyama
Jan 18, 2008·European Journal of Immunology·Kuo-Ching ShengGeoffrey A Pietersz
Jan 26, 2008·Nature Reviews. Cancer·Jason RiceFreda K Stevenson
May 20, 2008·Advanced Drug Delivery Reviews·Sophie Hernot, Alexander L Klibanov
Jul 25, 2008·European Journal of Immunology·Christian Kurts
Sep 23, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoichi NegishiYukihiko Aramaki
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·David A Hume
May 19, 2009·Human Gene Therapy·Hidefumi MukaiMitsuru Hashida
Jul 23, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ine LentackerNiek N Sanders

❮ Previous
Next ❯

Citations

Jan 18, 2013·Therapeutic Delivery·Srinivas Ramishetti, Leaf Huang
Nov 3, 2012·Therapeutic Delivery·Anthony DelalandeChantal Pichon
Feb 5, 2014·Biological & Pharmaceutical Bulletin·Shintaro Fumoto, Shigeru Kawakami
Apr 1, 2014·Advanced Drug Delivery Reviews·Johan Unga, Mitsuru Hashida
Jan 5, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tomoaki KurosakiMitsuru Hashida
Feb 4, 2014·Advanced Drug Delivery Reviews·Joshua J Rychak, Alexander L Klibanov
Aug 28, 2015·Expert Review of Vaccines·Lu ZhangShixia Wang
Sep 15, 2015·Expert Opinion on Drug Delivery·Małgorzata Anna MarćCarlos Gamazo
Jun 11, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shigeru Kawakami, Mitsuru Hashida
Mar 9, 2012·Biomaterials·Keerti JainNarendra K Jain
Jul 16, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Keita UnMitsuru Hashida
Jan 25, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keita UnMitsuru Hashida
Mar 31, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Fatemeh MovahediChenjie Xu
Nov 6, 2012·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Keita Un
Sep 4, 2015·Biomaterials Research·Jun YangXin Zhang
Apr 10, 2013·Gene·Anthony DelalandeChantal Pichon
Jun 24, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Tomoaki KurosakiMitsuru Hashida
Dec 21, 2011·Journal of Biomaterials Science. Polymer Edition·Hidefumi IshikawaYasuhiko Tabata
Jul 5, 2017·Chemical & Pharmaceutical Bulletin·Shintaro Fumoto, Koyo Nishida
Jul 5, 2017·Chemical & Pharmaceutical Bulletin·Masayori HagimoriShigeru Kawakami
Sep 11, 2020·Chembiochem : a European Journal of Chemical Biology·Gopikrishna MokuVenu Yakati
Jan 8, 2021·Proceedings of the National Academy of Sciences of the United States of America·Wei-Chen LoChih-Kuang Yeh
Jul 24, 2021·Cellular and Molecular Life Sciences : CMLS·Yi-Ju HoChih-Kuang Yeh
Aug 1, 2021·Advanced Drug Delivery Reviews·Shuang WangGuanghui Ma
Aug 2, 2021·Advanced Drug Delivery Reviews·Nisi ZhangKatherine W Ferrara

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.