PMID: 3746460Jul 1, 1986Paper

Development of anemia in copper-deficient rats fed high levels of dietary iron and sucrose

The Journal of Nutrition
M A Johnson, S S Hove

Abstract

The effects of dietary carbohydrate and iron on the development of copper deficiency were examined. Male Sprague-Dawley rats (n = 48) were limit-fed one of eight diets in a 2 X 2 X 2 factorial design for 19 d. Two levels of copper (0.85 or 8.6 micrograms Cu/g diet) and iron (54 or 226 micrograms Fe/g diet) and two types of carbohydrate (sucrose or cornstarch, 65.3%) were fed. Compared with control rats, copper-deficient rats had lower hematocrits, lower ceruloplasmin levels, lower tissue levels of copper and increased hepatic iron levels. Copper-deficient rats fed sucrose had significantly lower hematocrits, lower apparent absorption of copper, lower liver iron levels and higher plasma triglyceride levels than copper-deficient rats fed cornstarch. Copper-deficient rats fed sucrose with 226 micrograms Fe/g diet had hematocrit levels that were 15% lower than all other copper-deficient levels and 23% lower than control levels. Tissue levels of copper among copper-deficient rats were not affected by the type of carbohydrate or by the level of dietary iron. These data indicate that both high iron and sucrose can affect the development of the copper deficiency.

Citations

Jul 1, 1989·The British Journal of Nutrition·J R Prohaska
Aug 1, 1995·Journal of the American College of Nutrition·M FieldsW A Burns
Jun 1, 1993·Journal of the American College of Nutrition·M FieldsM D Lure
Jan 1, 1988·Clinical and Laboratory Haematology·S N Wickramasinghe
Feb 1, 1987·Nutrition Reviews
Jul 1, 1993·The British Journal of Nutrition·I A BrouwerA C Beynen
Dec 1, 1988·Biological Trace Element Research·H H Dollwet, J R Sorenson
Jul 1, 1987·Nutrition Reviews·M Fields, C Lewis
Jun 7, 2006·American Journal of Hematology·William HarlessJame Abraham
Dec 1, 1990·Nutrition Reviews·B L O'Dell
Jan 1, 1991·Metabolism: Clinical and Experimental·M FieldsW E Antholine

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