Abstract
The effects of dietary carbohydrate and iron on the development of copper deficiency were examined. Male Sprague-Dawley rats (n = 48) were limit-fed one of eight diets in a 2 X 2 X 2 factorial design for 19 d. Two levels of copper (0.85 or 8.6 micrograms Cu/g diet) and iron (54 or 226 micrograms Fe/g diet) and two types of carbohydrate (sucrose or cornstarch, 65.3%) were fed. Compared with control rats, copper-deficient rats had lower hematocrits, lower ceruloplasmin levels, lower tissue levels of copper and increased hepatic iron levels. Copper-deficient rats fed sucrose had significantly lower hematocrits, lower apparent absorption of copper, lower liver iron levels and higher plasma triglyceride levels than copper-deficient rats fed cornstarch. Copper-deficient rats fed sucrose with 226 micrograms Fe/g diet had hematocrit levels that were 15% lower than all other copper-deficient levels and 23% lower than control levels. Tissue levels of copper among copper-deficient rats were not affected by the type of carbohydrate or by the level of dietary iron. These data indicate that both high iron and sucrose can affect the development of the copper deficiency.
Citations
Jul 1, 1989·The British Journal of Nutrition·J R Prohaska
Aug 1, 1995·Journal of the American College of Nutrition·M FieldsW A Burns
Jun 1, 1993·Journal of the American College of Nutrition·M FieldsM D Lure
Jan 1, 1988·Clinical and Laboratory Haematology·S N Wickramasinghe
Feb 1, 1987·Nutrition Reviews
Jul 1, 1992·Biological Trace Element Research·E Weigand, M Kirchgessner
Jul 1, 1993·The British Journal of Nutrition·I A BrouwerA C Beynen
Mar 7, 2002·The Journal of Nutrition·Tanya TranMaria C Linder
Dec 1, 1988·Biological Trace Element Research·H H Dollwet, J R Sorenson
Jun 1, 1994·The British Journal of Nutrition·S YuA C Beynen
Sep 1, 1988·Biological Trace Element Research·M A Johnson, C L Murphy
Jul 1, 1987·Nutrition Reviews·M Fields, C Lewis
Jan 30, 2004·The Journal of Nutrition·Philip G ReevesHenry C Lukaski
Jun 7, 2006·American Journal of Hematology·William HarlessJame Abraham
Dec 1, 1990·Nutrition Reviews·B L O'Dell
Nov 1, 1995·General Pharmacology·B H Ali
Oct 1, 1994·General Pharmacology·T H Ben IsmailA A Bashir
Jan 1, 1991·Metabolism: Clinical and Experimental·M FieldsW E Antholine
Apr 1, 1997·Metabolism: Clinical and Experimental·M Fields, C G Lewis