Development of anti-human chorionic gonadotropin antibodies in patients with hypogonadotropic hypogonadism. A study of four patients

The Journal of Clinical Endocrinology and Metabolism
B ClaustratR Francois

Abstract

A young man with hypogonadotropic hypogonadism treated with hCG had resistance to this therapy and was found to have antibodies to hCG. We subsequently sought, using a sensitive radioimmunological method, anti-hCG antibodies in plasma from eight other hCG-treated children shown to have isolated hypogonadotropic hypogonadism. Antibodies to hCG were found in four of the nine. These antibodies were associated with the immunoglobulin fraction of plasma. In one patient antibodies were detected for 5 yr after therapy was discontinued. The titer and affinity constants of these antibodies were notably influenced by the therapeutic regimen used: the titer was significantly decreased and the affinity constant was lowered after reinstitution of therapy with larger hCG doses. In one patient the presence of anti-hCG antibody was associated with the failure to respond to hCG therapy.

Citations

Apr 25, 2000·Molecular and Cellular Endocrinology·M Zitzmann, E Nieschlag
Aug 26, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·S KitaharaH Oshima
Aug 2, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H-P HartungH Schellekens
Jan 16, 2007·European Journal of Endocrinology·Taneli RaivioLeo Dunkel
Nov 2, 2006·American Journal of Reproductive Immunology : AJRI·Seerin V ShataviJudith L Luborsky
Jul 18, 2002·Nature Reviews. Drug Discovery·Huub Schellekens
Mar 6, 2019·Frontiers in Endocrinology·Elodie KaraMarie-Christine Maurel
Dec 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·R B RaikowV W Andino

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