Development of anti-influenza agents from natural products.

Medicinal Research Reviews
Zhi-Jun ZhangRong-Tao Li

Abstract

The influenza pandemic continues to threaten public health due to its high morbidity and mortality rates, despite some successes in antiviral research. Natural drugs are important alternative therapies in the treatment of and recovery from influenza and have been the subjects of intense investigation during the last few decades. Many reports have shown that the development of novel bioactive chemicals extracted from natural drugs has significant advantages. Oseltamivir is a successful case of an anti-influenza drug synthesized using two natural products, quinic acid, and shikimic acid, as starting materials. In China, traditional Chinese medicine (TCM) plays an important role in the treatment of influenza. TCM herbal extracts and prescriptions or their isolated bioactive constituents have shown significant therapeutic and preventive effects against influenza. For example, the roots of Isatis indigotica (Banlangen) fight viral infection by targeting both the virus and the host and have significantly different effects than those of synthetic chemicals. Lianhuaqingwen capsule exerts its anti-influenza activity by regulating the immune response to interfere with both viral and host reactions and might well be an alternative therape...Continue Reading

References

Feb 1, 1980·The American Journal of Medicine·W B BaineS M Martin
Jan 6, 2001·Chemical & Pharmaceutical Bulletin·Y S YunM Satake
Aug 1, 1991·Social History of Medicine : the Journal of the Society for the Social History of Medicine·M L Hildreth
Mar 5, 2002·Bulletin of the History of Medicine·Niall P A S Johnson, Juergen Mueller
Sep 25, 2002·Bioorganic & Medicinal Chemistry Letters·Nobutoshi MurakamiMotomasa Kobayashi
Jan 28, 2003·Journal of Chemical Information and Computer Sciences·Miklos Feher, Jonathan M Schmidt
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Barry R O'KeefeMichael R Boyd
Jun 29, 2004·World Journal of Gastroenterology : WJG·Ai-Ping LuQing-Ping Lu
Feb 15, 2005·Journal of Virology·Ron A M FouchierAlbert D M E Osterhaus
Mar 25, 2005·Journal of Natural Products·Xiao Y WeiNai K Mak
Apr 19, 2006·Phytotherapy Research : PTR·Xiaoyan WangXiaorong Wang
Jun 7, 2006·Biological & Pharmaceutical Bulletin·Junping KouBoyang Yu
Nov 28, 2006·Vaccine·Dennis J Alexander
Feb 1, 1997·Planta medica·X WuG Qin
Nov 23, 2007·Natural Product Reports·Dwight D BakerVineet Rajgarhia
Nov 24, 2007·Journal of Chemical Information and Modeling·Peter ErtlAnsgar Schuffenhauer
May 28, 2008·Journal of Molecular Evolution·Rubing Chen, Edward C Holmes
Sep 16, 2008·Epidemiology and Infection·F DijkstraM A B Van Der Sande
Oct 15, 2008·Chinese Journal of Integrative Medicine·Yan-ling ZhaoXiao-he Xiao
Jun 16, 2009·Nature·Gabriele NeumannYoshihiro Kawaoka
Jun 23, 2009·Journal of Medicinal Chemistry·Gaopeng SongYingxia Li
Nov 7, 2009·The Journal of Antimicrobial Chemotherapy·Shin-Ru ShihJohn T-A Hsu
Dec 17, 2009·Fitoterapia·Qiaofeng WuXinxin Wen
Dec 18, 2009·Journal of Medicinal Chemistry·Ulrike GrienkeJudith M Rollinger
Dec 19, 2009·Science·Martin Enserink, Jon Cohen
Jan 5, 2010·Bioorganic & Medicinal Chemistry Letters·Nguyen Huu TungYoung Ho Kim
Jan 13, 2010·Bioorganic & Medicinal Chemistry Letters·Young Bae RyuWoo Song Lee
Jan 22, 2010·Journal of Natural Medicines·Rie SawamuraMasahiko Kurokawa
Apr 3, 2010·Archives of Pharmacal Research·Nguyen Huu TungYoung Ho Kim
Jul 31, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Kirsten van LangeveldeFrits R Rosendaal
Oct 12, 2010·Bioorganic & Medicinal Chemistry Letters·Phi Hung NguyenWon Keun Oh
Oct 14, 2010·Natural Product Reports·Hu GeHua Su
Nov 4, 2010·Antiviral Chemistry & Chemotherapy·Rie SawamuraMasahiko Kurokawa
Dec 3, 2010·Bioorganic & Medicinal Chemistry Letters·Trong Tuan DaoWon Keun Oh

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Citations

Oct 6, 2020·Expert Opinion on Therapeutic Patents·Tiziana Ginex, F Javier Luque
Jan 25, 2021·Journal of Ethnopharmacology·Zhonglei Wang, Liyan Yang
Jul 31, 2021·International Journal of Nanomedicine·Ran ChenJingqing Zhang

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