Development of Antiatherosclerotic Drugs on the basis of Natural Products Using Cell Model Approach

Oxidative Medicine and Cellular Longevity
Alexander N OrekhovYuri V Bobryshev

Abstract

Atherosclerosis including its subclinical form is one of the key medical and social problems. At present, there is no therapy available for widespread use against subclinical atherosclerosis. The use of synthetic drugs for the prevention of arteriosclerosis in its early stages is not sufficient because of the limited indications for severe side effects and high cost of treatment. Obviously, effective antiatherosclerotic drugs based on natural products would be a preferred alternative. Simple cell-based models for testing different natural products have been developed and the ability of natural products to prevent intracellular lipid accumulation in primary cell culture was evaluated. This approach utilizing cell models allowed to test effects of such direct antiatherosclerotic therapy, analyzing the effects mimicking those which can occur "at the level" of arterial wall via the inhibition of intracellular lipid deposition. The data from the carried out clinical trials support a point of view that the identification of antiatherosclerotic activity of natural products might offer a great opportunity for the prevention and treatment of atherosclerotic disease, reducing cardiovascular morbidity and mortality.

References

Jan 1, 1991·Circulation·K M AndersonW B Kannel
Feb 15, 1987·The American Journal of Cardiology·A N OrekhovV N Smirnov
Oct 9, 1998·Cardiovascular Research·P CarmelietD Collen
Sep 14, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·M H MoghadasianB M McManus
Jul 21, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Thomas Hartung, George Daston
Feb 14, 2012·Immunobiology·Alexei GratchevJulia Kzhyshkowska
Mar 3, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Godfrey S Getz, Catherine A Reardon
Aug 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Peter Libby
Oct 4, 2012·Current Opinion in Cardiology·Ashley SimmonsSarah Sanders
Nov 28, 2012·Recent Patents on Cardiovascular Drug Discovery·Alexander N OrekhovYuri V Bobryshev
Apr 18, 2013·Nutrition Reviews·Karin RiedPeter Fakler
Dec 18, 2013·Hämostaseologie·D WolfA Zirlik
Aug 27, 2014·Journal of Internal Medicine·L Badimon, G Vilahur
Nov 30, 2014·Endocrinology and Metabolism Clinics of North America·Evan A Stein, Frederick J Raal

❮ Previous
Next ❯

Citations

Mar 29, 2019·Biomolecules & Therapeutics·Jae-Yong Kim, Sang Hee Shim
Jul 31, 2019·Phytotherapy Research : PTR·Moumita KunduMahitosh Mandal
Jul 25, 2019·International Journal of Molecular Sciences·Volha I SummerhillAlexander N Orekhov
Aug 20, 2019·Recent Patents on Drug Delivery & Formulation·Sergei V Jargin
Apr 24, 2020·Frontiers in Pharmacology·Tatiana V KirichenkoGjumrakch Aliev
Oct 28, 2017·Frontiers in Pharmacology·Jian Fang, Yongjun Zhang
Mar 9, 2019·Recent Patents on Drug Delivery & Formulation·Sergei V Jargin
Jan 10, 2019·Current Drug Discovery Technologies·Alexander N OrekhovDimitry A Chistiakov
May 2, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shasha ZhengZhuyuan Fang

❮ Previous
Next ❯

Methods Mentioned

BETA
chemical modification

Clinical Trials Mentioned

NCT01734707
NCT01743404
NCT01742000

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

© 2021 Meta ULC. All rights reserved