Development of antibodies against pneumococcal proteins alpha-enolase, immunoglobulin A1 protease, streptococcal lipoprotein rotamase A, and putative proteinase maturation protein A in relation to pneumococcal carriage and Otitis Media

Vaccine
Peter V AdrianPeter W M Hermans

Abstract

Surface associated pneumococcal proteins alpha-enolase (Eno), immunoglobulin A1 protease (Iga), streptococcal lipoprotein rotamase A (SlrA), and putative proteinase maturation protein A (PpmA) have potential as candidates for future protein-based anti-pneumococcal vaccines. The immunogenicity of these proteins were studied in a cohort of 329 children during their first two years of life. During the first recorded episode of otitis media, acute and convalescent phase sera were available from 151 children. Concentrations of antibodies against Eno, Iga, SlrA and PpmA were measured by EIA and detected in 99% (300/302), 95% (288/302), 95% (288/302), and 83% (251/302) of the sera, respectively. There were no statistically significant differences between the groups of children with and without a history of pneumococcal contact or with respect to the type of pneumococcal contact. Despite a mean overall decrease in the antibody titers in the convalescent sera following AOM, several children were able to respond with a more than twofold increase in antibody titer in response to AOM. The majority of the children with increased antibody concentrations appeared in the groups, which were colonized with pneumococci at the time of serum collec...Continue Reading

References

Jun 12, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B Greenwood
Aug 10, 1999·The Pediatric Infectious Disease Journal·F GhaffarG H McCracken
Feb 6, 2002·The Journal of Experimental Medicine·Tera L McCoolJeffrey N Weiser
Mar 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey N WeiserEdward N Janoff

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Citations

Dec 8, 2005·Applied and Environmental Microbiology·Miriam MoscosoErnesto García
Nov 21, 2007·Journal of Bacteriology·Wouter T HendriksenPeter W M Hermans
Nov 19, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S ShomaA van Belkum
Sep 29, 2011·Infection and Immunity·Annemarie BoleijHarold Tjalsma
Aug 30, 2008·Critical Reviews in Microbiology·Gowrisankar RajamEdwin W Ades
Oct 21, 2015·Critical Reviews in Microbiology·Marijke PeetermansPeter Verhamme
Feb 10, 2007·Autoimmunity Reviews·Benjamin TerrierLuc Mouthon
Nov 4, 2006·Vaccine·Sandrine A L AudouyPeter W M Hermans
Apr 17, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M d M García-SuárezF J Méndez
Aug 11, 2016·FEBS Letters·Sylvia KohlerSven Hammerschmidt
Aug 30, 2016·Biochimica Et Biophysica Acta. General Subjects·Amit RahiRakesh Bhatnagar
Sep 9, 2011·Memórias do Instituto Oswaldo Cruz·Anil Kumar Ghosh, Marcelo Jacobs-Lorena
Jul 18, 2015·Molecular & Cellular Proteomics : MCP·Alfonso Olaya-AbrilManuel J Rodríguez-Ortega
Aug 3, 2012·Clinical and Vaccine Immunology : CVI·Ravinder KaurMichael E Pichichero
Sep 4, 2014·Microbiology and Molecular Biology Reviews : MMBR·Can M Ünala, Michael Steinert
Nov 2, 2005·The Journal of Biological Chemistry·Peter W M HermansSven Hammerschmidt
Mar 1, 2014·Emerging Microbes & Infections·Xiaolei PanJing-Ren Zhang
Jun 16, 2017·Current Otorhinolaryngology Reports·Caroline Bergenfelz, Anders P Hakansson
Jan 27, 2006·Microbiology·Simone Bergmann, Sven Hammerschmidt

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