Development of aortic and mitral valve continuity in the human embryonic heart

The American Journal of Anatomy
S I TealG M Hutchins

Abstract

The anatomic relationship of the aortic and mitral valves is a useful landmark in assessing congenital heart malformations. The atrioventricular and semilunar valve regions originate in widely separated parts of the early embryonic heart tube, and the process by which the normal fibrous continuity between the aortic and mitral valves is acquired has not been clearly defined. The development of the aortic and mitral valve relationship was studied in normal human embryos in the Carnegie Embryological Collection, and specimens of Carnegie stages 13, 15, 17, 19, and 23, prepared as serial histologic sections cut in the sagittal plane, were selected for reconstruction. In stage 13, the atrioventricular valve area is separated from the semilunar valve area by the large bend between the atrioventricular and outflow-tract components of the single lumen heart tube created by the left interventricular sulcus. In stages 15 and 17, the aortic valve rotates into a position near the atrioventricular valves with development of four chambers and a double circulation. In stage 19, there is fusion of aortic and mitral endocardial cushion material along the endocardial surface of the interventricular flange, and this relationship is maintained in...Continue Reading

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Citations

Dec 12, 2003·The Annals of Thoracic Surgery·Tomasz A TimekD Craig Miller
Aug 5, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Reginald Liew, David Ward
Sep 17, 2011·Clinical Genetics·Z-P TanY-F Yang
May 1, 1994·Early Human Development·J Wisser, P Dirschedl
Jan 6, 2004·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·L A Arráez-AybarJ Jiménez-Collado
Jan 1, 1995·Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association·K A Campbell, G M Hutchins
Jun 1, 1988·Circulation·G M HutchinsG W Moore
Aug 25, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Meng-Meng LiChang-Sheng Ma
Jan 21, 1988·The New England Journal of Medicine·A AngeliniM J Davies
Jan 1, 1988·Pediatric Pathology·G M Hutchins, G W Moore
Nov 7, 2020·Journal of the American College of Cardiology·Paolo FerrazziMaria Iascone

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