Development of aprepitant loaded orally disintegrating films for enhanced pharmacokinetic performance

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Radhika SharmaVikas Rana

Abstract

The present investigation was aimed to prepare orally disintegrating films (ODFs) containing aprepitant (APT), an antiemetic drug employing pullulan as film forming agent, tamarind pectin as wetting agent and liquid glucose as plasticizer and solubiliser. The ODFs were prepared using solvent casting method. The method was optimized employing 3(2) full factorial design considering proportion of pullulan: tamarind pectin and concentration of liquid glucose as independent variables and disintegration time, wetting time, folding endurance, tensile strength and extensibility as dependent variables. The optimized ODF was evaluated for various physicochemical, mechanical, drug release kinetics and bioavailability studies. The results suggested prepared film has uniform film surface, non-sticky and disintegrated within 18s. The in-vitro release kinetics revealed more than 87% aprepitant was released from optimized ODF as compared to 85%, 49%, and 12% aprepitant release from marketed formulation Aprecap, micronized aprepitant and non micronized aprepitant, respectively. The results of animal preference study indicated that developed aprepitant loaded ODFs are accepted by rabbits as food material. Animal pharmacokinetic (PK) study showed...Continue Reading

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Citations

Aug 9, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Gábor KatonaOrsolya Jójárt-Laczkovich
Mar 7, 2020·Drug Development and Industrial Pharmacy·Ting-Ting YanYan-Zhong Chen
Nov 30, 2018·The Journal of Pharmacy and Pharmacology·Ajinkya M BhagurkarMichael A Repka
Sep 15, 2020·International Journal of Pharmaceutics·Yoshiko TakeuchiHirofumi Takeuchi
Mar 2, 2021·International Journal of Biological Macromolecules·Murilo Santos PachecoMariana Agostini de Moraes
Mar 7, 2021·International Journal of Molecular Sciences·Theodora ChristoforidouDimitrios G Fatouros
Aug 15, 2021·AAPS PharmSciTech·Neha Vishal GandhiSachidanand Shankar Angadi
Sep 3, 2020·Drug Metabolism Letters·Preethi SudheerKavitha A Narayana

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