PMID: 11310500Apr 20, 2001Paper

Development of astrocytes in the mouse embryonic cerebrum tracked by tenascin-C gene expression

Archives of Histology and Cytology
S Yuasa

Abstract

The development of astrocytes in the rodent cerebrum has been considered to occur mainly in the perinatal stage after the end of neurogenesis, and the mode of generation and migration of the astroglial precursors in the embryonic cerebrum remains poorly understood. Tenascin-C (TN-C) is an astroglia-derived extracellular matrix molecule, and its expression can be traced to the ventricular germinative zone of the embryonic cerebrum. TN-C expression may therefore be used as a marker of astroglial precursors prior to the expression of the glial fibrillary acidic protein (GFAP), a marker for the late stage of astroglial differentiation. The development of astrocytes in the mouse embryonic cerebrum was examined by in situ hybridization histochemistry for TN-C mRNA as an early marker. Observations showed that TN-C-positive cells were aligned in the ventricular germinative zone and began to migrate radially at E (embryonic day) 15. They were dispersed into the cortex as early as E17, and some were still in the DNA synthetic phase (S phase) even after lodgement in the cortex. TN-C-positive cells differentiated into GFAP-immunopositive astrocytes in the cortical and subcortical areas at the neonatal stage. The distribution of their activ...Continue Reading

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Citations

Apr 14, 2012·International Journal of Endocrinology·T J WhitmoreP E Hartmann
Dec 28, 2007·Cells, Tissues, Organs·Alexander von Holst
Apr 12, 2005·BMC Neuroscience·Michaela RickChristoph S Clemen
May 21, 2008·Neurological Research·Hiroko Ikeshima-Kataoka, Shigeki Yuasa
Aug 16, 2016·International Journal of Molecular Sciences·Hiroko Ikeshima-Kataoka
Oct 30, 2003·Nature Neuroscience·Fiona Doetsch
Feb 1, 2007·The Journal of Biological Chemistry·Alexander von HolstAndreas Faissner

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