Development of axonal arbors of layer 6 pyramidal neurons in ferret primary visual cortex

The Journal of Comparative Neurology
E M Callaway, J L Lieber

Abstract

We followed the development of axonal arbors of layer 6 pyramidal neurons in ferret striate cortex to determine whether early developing axon collaterals are formed specifically in the correct target layers from the outset or achieve their adult specificity by the elimination of initially exuberant projections. These neurons were chosen for study because they are amongst the first to be generated in the developing ferret's striate cortex, and, in mature animals, these cells have axonal arbors that are highly specific for layer 4 and to a lesser extent layers 2/3 but have few collateral branches in layer 5. The axonal arbors of individual layer 6 pyramidal neurons were reconstructed following labeling in living slices prepared from the striate cortex of ferrets aged 13-35 days postnatal (P13-35). At the earliest ages (P13-15), axonal arbors consisted of a simple axon extending from the base of the cell body into the subplate or white matter and usually forming a few collateral branches but never ascending into layer 5. By P19-20, about one-half of the cells had extended axon collaterals into layer 5 or higher, and these already appeared to branch preferentially in layer 4. All of the cells from older animals had substantial axon...Continue Reading

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Citations

Dec 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cuiping ZhaoPatrick O Kanold
Oct 5, 2002·Journal of Neurophysiology·Michael Beierlein, Barry W Connors
Feb 13, 2001·The Journal of Comparative Neurology·A K ButlerE M Callaway
Dec 2, 2005·The Journal of Comparative Neurology·DeLaine D Larsen, Edward M Callaway
Jun 25, 2010·The Journal of Comparative Neurology·Joanna J RowellClifton W Ragsdale
Jul 11, 2000·The Journal of Comparative Neurology·M A KingsburyB L Finlay
Feb 10, 1999·The Journal of Comparative Neurology·J J Prieto, J A Winer
May 24, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jessica M SnyderSandra E Juul

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