Development of benchmark quality criteria for assessing whole-endoscopy Barrett's esophagus biopsy cases

United European Gastroenterology Journal
M J van der WelSybren L Meijer

Abstract

Dysplasia in Barrett's esophagus (BE) biopsies is associated with low observer agreement among general pathologists. Therefore, expert review is advised. We are developing a web-based, national expert review panel for histological review of BE biopsies. The aim of this study was to create benchmark quality criteria for future members. Five expert BE pathologists, with 10-30 years of BE experience, weekly handling 5-10 cases (25% dysplastic), assessed a case set of 60 digitalized cases, enriched for dysplasia. Each case contained all slides from one endoscopy (non-dysplastic BE (NDBE), n = 21; low-grade dysplasia (LGD), n = 20; high-grade dysplasia (HGD), n = 19). All cases were randomized and assessed twice followed by group discussions to create a consensus diagnosis. Outcome measures: percentage of 'indefinite for dysplasia' (IND) diagnoses, intra-observer agreement, and agreement with the consensus 'gold standard' diagnosis. Mean percentage of IND diagnoses was 8% (3-14%) and mean intra-observer agreement was 0.84 (0.66-1.02). Mean agreement with the consensus diagnosis was 90% (95% prediction interval (PI) 82-98%). Expert pathology review of BE requires the scoring of a limited number of IND cases, consistency of assessment...Continue Reading

References

Jan 4, 2001·The Netherlands Journal of Medicine·J B HulscherUNKNOWN Barrett Advisory Committee
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Sep 9, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M J van der WelS L Meijer

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Citations

Jun 9, 2021·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M J van der WelJ J G H M Bergman

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

Statistical Package for the Social Sciences ( SPSS
Agreestat

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