PMID: 8950955Nov 1, 1996Paper

Development of beta 2-selective, long-acting agonists

Nihon rinsho. Japanese journal of clinical medicine
N Inagaki, H Nagai

Abstract

beta 2-Agonists have been the main bronchodilator drugs used in the symptomatic treatment of asthma. Regular use of beta 2-agonists, however, is well known to produce tolerance to their bronchoprotective effect. It has been pointed out that the over-treatment with beta 2-agonists may be associated with worsening asthma and increased risk of life-threatening attacks. To reduce the cardiovascular side effects, compounds with advanced beta 2-selectivity have been examined and established. Newly developed beta 2-selective agonists are structurally stable and long-acting. Some of them are reported to be effective for treatment of late asthmatic response, although conventional beta-agonists are thought to be relatively ineffective.

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.