Development of beta-lactamase-mediated resistance to penicillin in middle-ear isolates of Moraxella catarrhalis in Finnish children, 1978-1993

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
A NissinenP H Mäkelä

Abstract

The frequency of beta-lactamase production was analyzed in a study of 1,452 strains of Moraxella catarrhalis and 2,738 strains of Haemophilus influenzae isolated from middle-ear fluid of children < 6 years of age at Tampere University Hospital in Tampere, Finland, between 1978 and 1993. In addition, 401 isolates of M. catarrhalis from similar samples collected in different parts of Finland in 1988-1990 were tested for beta-lactamase production; minimal inhibitory concentrations of ampicillin, cefaclor, cephalothin, erythromycin, tetracycline, and trimethoprim-sulfamethoxazole for these strains were determined. These data were compared with figures for the annual consumption of beta-lactam antimicrobials in the community in 1978-1993. A bimodal increase in the proportion of strains of M. catarrhalis producing beta-lactamase was detected: from 0 to 60% in 1978-1983 and from 60% to 80% in 1988-1990. Concurrently with the second increase, the consumption of cephalosporins increased substantially in the community. The frequency of beta-lactamase-producing strains of H. influenzae did not increase between 1978 and 1993.

Citations

Oct 5, 2002·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·N BruinsmaE E Stobberingh
Apr 30, 2008·Antimicrobial Agents and Chemotherapy·Pauliina KärpänojaUNKNOWN Finnish Study Group for Antimicrobial Resistance (FiRe Network)
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Jan 17, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jack B AnonUNKNOWN Sinus And Allergy Health Partnership
Feb 4, 1999·Nature Medicine·R M Anderson
Oct 22, 2003·The Pediatric Infectious Disease Journal·Jerome O Klein
May 31, 2003·Nature Reviews. Genetics·Diarmaid Hughes
Jun 12, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D J Austin, R M Anderson
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Aug 11, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Johanna Björkman, Dan I. Andersson

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