Development of bioactive sodium alginate/sulfonated polyether ether ketone/hydroxyapatite nanocomposites: Synthesis and in-vitro studies.

Carbohydrate Polymers
Esmaeil Salimi

Abstract

Developing bioactive composites to fill bone cavities caused by disease, injury or surgery still remains a challenge. The aim of this research was to develop a new nanostructured sodium alginate/sulfonated polyether ether ketone/nano-hydroxyapatite (Alg/SPEEK/HA) biocomposite via a simple chemical precipitation strategy. Structural analysis was carried out using X-ray diffraction (XRD), Fourier transformation infrared spectroscopy (FTIR). Thermogravimetric analysis (TGA) was used to compare the HA content of the composites. The in-vitro bioactivity of the composites with different content of HA was investigated by immersing the specimens in the simulated body fluid (SBF) for 15 days. The presence of HA in the composite structure gave rise to the precipitation of an apatite layer on the surface, which was increased by increase in the content of HA. The formation of the HA layer on the composite surface was scrutinized via FESEM and EDX analysis. Transmission electron microscopy (TEM) images exhibited the presence of HA nanoparticles with less than 30 nm in size. The in-vitro cytotoxicity evaluation was also carried out using MG-63 cells via the MTT assay, which revealed that the cytocompatibility of all specimens was increased w...Continue Reading

References

Jan 16, 1998·Journal of Biomedical Materials Research·H YildizF K Chang
Jan 16, 1998·Journal of Biomedical Materials Research·H YildizS Goodman
Oct 31, 2000·Biomaterials·J C Middleton, A J Tipton
Mar 12, 2002·The Journal of Bone and Joint Surgery. American Volume·Christopher G Finkemeier
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·J HuangW Bonfield
Jan 1, 2005·Biomaterials·Zhensheng LiMiqin Zhang
Feb 2, 2006·Biomaterials·Tadashi Kokubo, Hiroaki Takadama
Nov 17, 2006·Journal of Biomedical Materials Research. Part a·Ren HuHai-Yan Shi
Sep 20, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yu-Cheng ChouShin-Yuan Chen
Jan 31, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Amir A Al-MunajjedFergal J O'Brien
Oct 16, 2010·Marine Drugs·Jayachandran Venkatesan, Se-Kwon Kim
May 15, 2013·International Journal of Biological Macromolecules·Kemal BaysalBahattin M Baysal
Jul 16, 2014·International Journal of Biological Macromolecules·Jayachandran VenkatesanSe-Kwon Kim
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Juan F D MonteroJúlio C M Souza
May 20, 2018·International Journal of Biological Macromolecules·Bahador Safikhani GholizadehSeyed Mohammad Mousavi
Apr 6, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Yong-Guang BiShi-Ting Deng
Mar 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bapi SarkerAldo R Boccaccini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.