Development of biocompatible glycodynameric hydrogels joining two natural motifs by dynamic constitutional chemistry

Carbohydrate Polymers
Luminita MarinLiliana Tartau-Mititelu

Abstract

The paper focusses on the synthesis of novel hydrogels by joining natural biodegradable compounds with the aim to achieve biocompatible materials for bio related applications. The hydrogels were prepared from chitosan and citral by constitutional dynamic chemistry, incorporating both molecular and supramolecular dynamic features. The hydrophobic flexible citral has been reversible immobilized onto the hydrophilic chitosan backbone via imine bonds to form amphiphilic glycodynamers, which further self-ordered through supramolecular interactions into a 3D-network of biodynameric hydrogel. The synthetic pathway has been demonstrated by NMR and FTIR spectroscopy, X-ray diffraction and polarized light microscopy. Studies of the hydrogel morphology revealed a 3D porous microstructure, whose pores size correlated with the crosslinking degree. Rheological investigations evidenced high elasticity, thermo-responsiveness and thixotropic behavior. As a proof of the concept, the hydrogels proved in vivo biocompatibility on laboratory mice. The paper successfully implements the constitutional dynamic chemistry in generation of chitosan high performance hydrogels.

Citations

Mar 7, 2019·Royal Society Open Science·Wen ShenGuodong Fan
Sep 6, 2019·Computational and Mathematical Methods in Medicine·Anda-Mihaela CraciunLăcrămioara Ochiuz
Jul 31, 2020·Materials·Mariana PintealaRadu D Rusu
Aug 17, 2019·Current Medicinal Chemistry·Javad TavakoliYouhong Tang
Oct 28, 2018·Journal of Colloid and Interface Science·Anda Mihaela CraciunLuminita Marin
Jan 28, 2021·Drug Delivery·Daniela AilincaiConstantin Volovat
May 1, 2018·Ultrasonics Sonochemistry·Manuela Maria Iftime, Luminita Marin

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