Development of biodegradable poly(propylene fumarate)/poly(lactic-co-glycolic acid) blend microspheres. I. Preparation and characterization

Journal of Biomedical Materials Research. Part a
Diederik H R KempenMichael J Yaszemski

Abstract

We developed poly(propylene fumarate)/poly(lactic-co-glycolic acid) (PPF/PLGA) blend microspheres and investigated the effects of various processing parameters on the characteristics of these microspheres. The advantage of these blend microspheres is that the carbon-carbon double bonds along the PPF backbone could be used for their immobilization in a PPF scaffold. Microspheres containing the model drug Texas red dextran were fabricated using a double emulsion-solvent extraction technique. The effects of the following six processing parameters on the microsphere characteristics were investigated: PPF/PLGA ratio, polymer viscosity, vortex speed during emulsification, amount of internal aqueous phase, use of poly(vinyl alcohol) (PVA) in the internal aqueous phase, and PVA concentration in the external aqueous phase. Our results showed that the microsphere surface morphology was affected most by the viscosity of the polymer solution. Microspheres fabricated with a kinematic viscosity of 39 centistokes had a smooth, nonporous surface. In most microsphere formulations, the model drug was dispersed uniformly in the polymer matrix. For all fabricated formulations, the average microsphere diameter ranged between 19.0 and 76.9 microm. T...Continue Reading

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Citations

Nov 11, 2006·Journal of Biomaterials Science. Polymer Edition·W J E M HabrakenJ A Jansen
Jun 2, 2007·Advanced Drug Delivery Reviews·Marina Sokolsky-PapkovAbraham J Domb
Sep 30, 2010·Journal of Biomedical Materials Research. Part a·Ralph de BoerAnthony J Windebank
Feb 13, 2013·Journal of Biomedical Materials Research. Part a·Michael B DreifkeAmbalangodage C Jayasuriya
Apr 3, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wouter F WillemsAllen T Bishop
Mar 30, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wouter F WillemsAllen T Bishop
Nov 14, 2018·Journal of Biomedical Materials Research. Part a·Jingfeng LiLichun Lu
Jan 5, 2006·Journal of Biomedical Materials Research. Part a·Diederik H R KempenMichael J Yaszemski

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