Abstract
This article describes the effects of six processing parameters on the release kinetics of a model drug Texas red dextran (TRD) from poly(propylene fumarate)/poly(lactic-co-glycolic acid) (PPF/PLGA) blend microspheres as well as the degradation of these microspheres. The microspheres were fabricated using a double emulsion-solvent extraction technique in which the following six parameters were varied: PPF/PLGA ratio, polymer viscosity, vortex speed during emulsification, amount of internal aqueous phase, use of poly(vinyl alcohol) in the internal aqueous phase, and poly(vinyl alcohol) concentration in the external aqueous phase. We have previously characterized these microspheres in terms of microsphere morphology, size distribution, and TRD entrapment efficiency. In this work, the TRD release profiles in phosphate-buffered saline were determined and all formulations showed an initial burst release in the first 2 days followed by a decreased sustained release over a 38-day period. The initial burst release varied from 5.1 (+/-1.1) to 67.7 (+/-3.4)% of the entrapped TRD, and was affected most by the viscosity of the polymer solution used for microsphere fabrication. The sustained release between day 2 and day 38 ranged from 7.9 ...Continue Reading
References
Sep 1, 1992·Pharmaceutical Research·S RoyB K Gupta
Jun 1, 1991·Pharmaceutical Research·S CohenR Langer
Jul 1, 1986·Journal of Microencapsulation·K MakinoT Kondo
Oct 1, 1995·Biomaterials·T G Park
Jan 1, 1996·Biomaterials·A Göpferich
Oct 31, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y H ChengS S Davis
Feb 27, 1999·Biomaterials·X Cao, M S Schoichet
Jun 24, 1999·Journal of Biomedical Materials Research·L LuA G Mikos
Mar 29, 2000·Journal of Biomedical Materials Research·L LuA G Mikos
Jul 6, 2000·Journal of Biomedical Materials Research·T W King, C W Patrick
Jul 8, 2000·Biomaterials·L LuA G Mikos
Aug 3, 2000·Journal of Biomechanical Engineering·B D PorterM J Yaszemski
Feb 24, 2001·Biomaterials·Y Y YangN P Ng
Mar 20, 2001·Journal of Biomedical Materials Research·J J Yoon, T G Park
Feb 22, 2002·Journal of Biomedical Materials Research·Johan W M VehofJohn A Jansen
Jul 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cory BerklandDaniel W Pack
Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Juan WangSteven P Schwendeman
Nov 20, 2002·Biomaterials·Mark D TimmerAntonios G Mikos
Dec 7, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elizabeth L HedbergAntonios G Mikos
Jan 14, 2003·Pharmaceutical Research·Juergen SiepmannJean-Pierre Benoit
Citations
Jun 29, 2007·Journal of Materials Science. Materials in Medicine·Esmaiel Jabbari, Xuezhong He
Dec 17, 2008·Pharmaceutical Research·Esmaiel Jabbari
Oct 25, 2011·Acta Biomaterialia·Jing RuiHuan Wang
Jun 2, 2007·Advanced Drug Delivery Reviews·Marina Sokolsky-PapkovAbraham J Domb
Apr 24, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Huaping TanChangyou Gao
Aug 7, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Haiguang ZhaoJiacong Shen
Feb 18, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mikko LarsenAllen T Bishop
Apr 3, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wouter F WillemsAllen T Bishop
Jan 22, 2011·Journal of Biomedical Materials Research. Part a·Aicha AbedAnne Meddahi-Pellé
Nov 30, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tiago MattarAllen T Bishop
Mar 30, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wouter F WillemsAllen T Bishop
Jan 8, 2014·Microsurgery·Mikko LarsenAllen T Bishop
May 15, 2007·Journal of Biomaterials Applications·Meital Zilberman, Orly Grinberg
Aug 3, 2006·Journal of Biomedical Materials Research. Part a·Meital Zilberman, Inbal Shraga
May 22, 2007·Journal of Biomedical Materials Research. Part a·H UedaA G Mikos
Jan 5, 2006·Journal of Biomedical Materials Research. Part a·Diederik H R KempenMichael J Yaszemski
Nov 14, 2016·ACS Biomaterials Science & Engineering·Mehrnaz SalarianPaul A Charpentier