Development of biodegradable poly(propylene fumarate)/poly(lactic-co-glycolic acid) blend microspheres. II. Controlled drug release and microsphere degradation

Journal of Biomedical Materials Research. Part a
Diederik H R KempenMichael J Yaszemski

Abstract

This article describes the effects of six processing parameters on the release kinetics of a model drug Texas red dextran (TRD) from poly(propylene fumarate)/poly(lactic-co-glycolic acid) (PPF/PLGA) blend microspheres as well as the degradation of these microspheres. The microspheres were fabricated using a double emulsion-solvent extraction technique in which the following six parameters were varied: PPF/PLGA ratio, polymer viscosity, vortex speed during emulsification, amount of internal aqueous phase, use of poly(vinyl alcohol) in the internal aqueous phase, and poly(vinyl alcohol) concentration in the external aqueous phase. We have previously characterized these microspheres in terms of microsphere morphology, size distribution, and TRD entrapment efficiency. In this work, the TRD release profiles in phosphate-buffered saline were determined and all formulations showed an initial burst release in the first 2 days followed by a decreased sustained release over a 38-day period. The initial burst release varied from 5.1 (+/-1.1) to 67.7 (+/-3.4)% of the entrapped TRD, and was affected most by the viscosity of the polymer solution used for microsphere fabrication. The sustained release between day 2 and day 38 ranged from 7.9 ...Continue Reading

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Citations

Jun 29, 2007·Journal of Materials Science. Materials in Medicine·Esmaiel Jabbari, Xuezhong He
Dec 17, 2008·Pharmaceutical Research·Esmaiel Jabbari
Jun 2, 2007·Advanced Drug Delivery Reviews·Marina Sokolsky-PapkovAbraham J Domb
Apr 24, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Huaping TanChangyou Gao
Aug 7, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Haiguang ZhaoJiacong Shen
Apr 3, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wouter F WillemsAllen T Bishop
Jan 22, 2011·Journal of Biomedical Materials Research. Part a·Aicha AbedAnne Meddahi-Pellé
Nov 30, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tiago MattarAllen T Bishop
Mar 30, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wouter F WillemsAllen T Bishop
Aug 3, 2006·Journal of Biomedical Materials Research. Part a·Meital Zilberman, Inbal Shraga
May 22, 2007·Journal of Biomedical Materials Research. Part a·H UedaA G Mikos
Jan 5, 2006·Journal of Biomedical Materials Research. Part a·Diederik H R KempenMichael J Yaszemski
Nov 14, 2016·ACS Biomaterials Science & Engineering·Mehrnaz SalarianPaul A Charpentier

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