Development of biodegradable polyurethane and bioactive glass nanoparticles scaffolds for bone tissue engineering applications

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Agda Aline Rocha de OliveiraMarivalda de Magalhães Pereira

Abstract

The development of polymer/bioactive glass has been recognized as a strategy to improve the mechanical behavior of bioactive glass-based materials. Several studies have reported systems based on bioactive glass/biopolymer composites. In this study, we developed a composite system based on bioactive glass nanoparticles (BGNP), obtained by a modified Stöber method. We also developed a new chemical route to obtain aqueous dispersive biodegradable polyurethane. The production of polyurethane/BGNP scaffolds intending to combine biocompatibility, mechanical, and physical properties in a material designed for tissue engineering applications. The composites obtained were characterized by structural, biological, and mechanical tests. The films presented 350% of deformation and the foams presented pore structure and mechanical properties adequate to support cell growth and proliferation. The materials presented good cell viability and hydroxyapatite layer formation upon immersion in simulated body fluid.

References

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Citations

May 9, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Breno Rocha BarrioniMarivalda de Magalhães Pereira
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Lijun JiXiaoli Song
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Cheisy D F MoreiraMarivalda M Pereira
Jun 5, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Ehsan ZeimaranMark R Towler
Jun 25, 2019·Journal of Biomaterials Science. Polymer Edition·Fernando Javier Aguilar-PérezYadir Torres-Hernández
Dec 26, 2015·Journal of Materials Science. Materials in Medicine·Taylor E KavanaughJuan V Cauich-Rodríguez
Jan 16, 2016·Journal of Biomaterials Applications·Fernando J Aguilar-PérezMerhdad Pedram-Yazdani
May 5, 2018·Journal of Biomaterials Applications·Fernando Javier Aguilar-PerezJose Antonio Rodriguez-Ortiz
Apr 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·S M Cetina-DiazJ V Cauich-Rodríguez
Aug 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shan-Hui HsuJui-Che Lin

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