PMID: 2501789Jul 1, 1989Paper

Development of biologically active peptides based on antibody structure

Proceedings of the National Academy of Sciences of the United States of America
W V WilliamsM I Greene

Abstract

Antibody molecules are composed of several functional domains, including a variable domain that contacts antigen and a constant domain. The hypervariable regions of antibody molecules play an integral role in determining their specificity. However, the delineation of specific residues most critical in binding is difficult. We have been studying a monoclonal antibody (87.92.6) that binds to the reovirus type 3 receptor on a number of cell types, down-modulates the receptor, and inhibits DNA synthesis in the cells. We have shown that a peptide derived from the second complementarity-determining region of the monoclonal antibody 87.92.6 light-chain variable region can reproduce both of these effects. We were also able to demonstrate specific amino acid residues and structural features involved in producing these effects. The study of antibody structure, coupled with molecular synthetic techniques, can lead to the development of biologically active substances with potential clinical use.

References

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Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C BruckM I Greene
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Citations

Mar 1, 1994·Journal of Molecular Recognition : JMR·M Malmqvist
Apr 1, 1995·Molecular Biotechnology·R Rapley
Jan 1, 1994·Immunologic Research·T Kieber-EmmonsM P Madaio
Jan 1, 1992·Immunologic Research·W V WilliamsM I Greene
Oct 1, 1994·Molecular Immunology·E DöringJ Schneider-Mergener
Jul 1, 1990·Trends in Biotechnology·R A Spooner, J M Lord
Sep 1, 1990·Biochimie·G Lefranc, M P Lefranc
May 10, 2005·Molecular Immunology·Weisong QinBeifen Shen
Jul 19, 1990·The New England Journal of Medicine·R D Mayforth, J Quintáns
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J A CohenM I Greene
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J A CohenM I Greene
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M LeviB Wahren
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E Cordella-MieleA B Mukherjee
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B WangD B Weiner
Apr 1, 1992·DNA and Cell Biology·J M Von FeldtW V Williams
Aug 6, 1998·Bioscience, Biotechnology, and Biochemistry·R TakataS Hatano
Aug 26, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·D LauneC Granier
Jan 1, 1994·Immunologic Research·J M Von FeldtW V Williams
Jan 1, 1993·Cancer Investigation·N Hozumi, J S Sandhu
Jan 1, 2012·Pharmaceuticals·Ramachandran Murali, Mark I Greene
Nov 2, 1989·Nature·J D Rodwell
Jan 24, 1991·Nature·G Winter, C Milstein
Jan 1, 1992·Critical Reviews in Biotechnology·J S Sandhu
Feb 9, 1996·The Journal of Biological Chemistry·C MonfardiniW V Williams
Mar 24, 1995·The Journal of Biological Chemistry·C MonfardiniD E McCallus
May 26, 2005·The Journal of General Virology·Caroline J HeapNigel J Dimmock
Jan 26, 2002·Molecular and Cellular Biology·Richard ChanWilliam J Muller
Sep 1, 1991·European Journal of Immunology·T KoizumiR S Schwartz
Mar 7, 2002·International Reviews of Immunology·G Cunto-AmestyT Kieber-Emmons
Jan 30, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anat BurkovitzYanay Ofran

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