Development of biomimetic nanocomposites as bone extracellular matrix for human osteoblastic cells

Carbohydrate Polymers
Arundhati BhowmickPatit Paban Kundu

Abstract

Here, we have developed biomimetic nanocomposites containing chitosan, poly(vinyl alcohol) and nano-hydroxyapatite-zinc oxide as bone extracellular matrix for human osteoblastic cells and characterized by Fourier transform infrared spectroscopy, powder X-ray diffraction. Scanning electron microscopy images revealed interconnected macroporous structures. Moreover, in this study, the problem related to fabricating a porous composite with good mechanical strength has been resolved by incorporating 5wt% of nano-hydroxyapatite-zinc oxide into chitosan-poly(vinyl alcohol) matrix; the present composite showed high tensile strength (20.25MPa) while maintaining appreciable porosity (65.25%). These values are similar to human cancellous bone. These nanocomposites also showed superior water uptake, antimicrobial and biodegradable properties than the previously reported results. Compatibility with human blood and pH was observed, indicating nontoxicity of these materials to the human body. Moreover, proliferation of osteoblastic MG-63 cells onto the nanocomposites was also observed without having any negative effect.

References

Feb 1, 1993·Journal of Biomedical Materials Research·A G MikosR Langer
Jan 1, 1996·Biomaterials·E WintermantelM Mathey
Nov 24, 1999·International Journal of Biological Macromolecules·K OkuyamaK Ogawa
Jul 6, 2000·Journal of Biomedical Materials Research·T J WebsterR Bizios
Jul 25, 2000·Biomaterials·T J WebsterR Bizios
Apr 18, 2003·Biomaterials·Eugene Khor, Lee Yong Lim
Feb 29, 2008·Journal of Biomedical Materials Research. Part a·Betsy M ChesnuttJoel D Bumgardner
Sep 19, 2008·Pharmaceutical Development and Technology·Tanasait NgawhirunpatPitt Supaphol
Jan 6, 2009·Acta Biomaterialia·W W Thein-Han, R D K Misra
May 28, 2009·Biotechnology and Bioengineering·Mark W Tibbitt, Kristi S Anseth
Oct 6, 2009·Advanced Drug Delivery Reviews·T Kean, M Thanou
Aug 19, 2010·Expert Opinion on Drug Delivery·John W RasmussenDenise G Wingett
Aug 26, 2010·Tissue Engineering. Part B, Reviews·Katerina GkioniJohn A Jansen
May 20, 2011·Colloids and Surfaces. B, Biointerfaces·Venkataraman DeepakSangiliyandi Gurunathan
Nov 30, 2011·International Journal of Biological Macromolecules·Anjali TripathiNagarajan Selvamurugan
Dec 14, 2011·The Journal of Bone and Joint Surgery. American Volume·Chad Myeroff, Michael Archdeacon
Sep 4, 2012·Trends in Biotechnology·Susmita BoseAmit Bandyopadhyay

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacillus Cereus Infection

Bacillus Cereus is a gram-positive bacteria that is the cause of some foodborne illnesses and leads to diarrhea and vomiting. Discover the latest research on Bacillus Cereus Infection here.

Related Papers

International Journal of Biological Macromolecules
Mithilesh Yadav, Sharif Ahmad
International Journal of Biological Macromolecules
Zhi-Hong ZhangYu-Jia Liu
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
X YuanFei He
International Journal of Biological Macromolecules
Tapas Kumar GhoshDipankar Chattopadhyay
© 2022 Meta ULC. All rights reserved