Development of brown adipose tissue thermogenesis in the ovine fetus and newborn

Endocrinology
A H KleinD A Fisher

Abstract

Despite the importance of brown adipose tissue (BAT) in the regulation of thermogenesis and energy expenditure in both newborn and adult mammals, the functional ontogenesis of this tissue is largely unknown. In the present study, we describe the maturation of several aspects of BAT thermogenesis in fetal and newborn sheep. Cell respiration of brown adipocytes isolated from perirenal BAT was measured using a Gilson differential respirometer. Cells were isolated from four fetal animals at 121-124 days gestation (group 1), five fetal animals at 137-140 days gestation (group 2), and five newborns between birth and 4 days of age (group 3). In addition to basal oxygen consumption, in vitro cell respiration also was measured after the addition of norepinephrine (NE), (Bu)2cAMP, alpha-glycerophosphate (alpha GP), and butyric acid. Mean (+/- SEM) basal respiration (in microliters of O2 per 10(6) cells/h) increased from 11 +/- 1 in group 1 to 31 +/- 2 in group 2 and 45 +/- 7 in group 3. Cell volume increased from 9 +/- 1 pl in group 1 to 13 +/- 2 pl in group 2 and 18 +/- 2 pl in group 3. After adjustment for variations in basal respiration due to differences in cell volume, basal respiration in group 2 was greater than that in group 1 an...Continue Reading

Citations

Aug 18, 1995·Early Human Development·T R Gunn, P D Gluckman
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·D A FisherS Y Wu
May 1, 1993·American Journal of Medical Genetics·P WrightR M Murray
Jan 1, 1990·The American Journal of the Medical Sciences·S Y WuW Florsheim
Nov 1, 1989·Baillière's Clinical Endocrinology and Metabolism·T R Gunn, P D Gluckman
Oct 12, 2013·Reproduction in Domestic Animals = Zuchthygiene·M MutinatiR L Sciorsci
Jun 1, 1991·The Journal of Applied Bacteriology·E Jonsson, S Hemmingsson
May 23, 2020·Animal Science Journal = Nihon Chikusan Gakkaihō·Eloy RedondoJavier Masot
Mar 1, 1997·Zentralblatt für Veterinärmedizin. Reihe A·P GuilloteauJ W Blum
Oct 13, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anu VaidyanathanJoseph C Beyer
Aug 2, 2011·Applied and Environmental Microbiology·Keren Buhnik-RosenblauYechezkel Kashi
Dec 1, 1996·Journal of Applied Physiology·K T BallG G Power
Apr 1, 1987·The American Journal of Physiology·J F PadburyJ A Humme

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