Development of calcitonin gene-related peptide slow-release tablet implanted in CSF space for prevention of cerebral vasospasm after experimental subarachnoid haemorrhage

Acta neurochirurgica
I AhmadT Yoshimoto

Abstract

The calcitonin gene-related peptide (CGRP), a known potent intrinsic cerebral vasodilator, is contained in the sensory nerves from trigeminal ganglia that inervate the cerebral arteries. We previously reported that human alpha CGRP (hCGRP) dilates spastic cerebral arteries after experimental subarachnoid haemorrhage (SAH) in rabbits. In the present study, we investigated the prophylactic potential of a sustained higher cerebrospinal fluid level of hCGRP against experimental cerebral vasospasm. An hCGRP slow-release tablet (hCGRP s-r tablet) was developed for cisternal implantation. Experimental SAH was induced by percutaneous cisternal injection of autologous arterial blood. Angiography was initiated on day 1 (before SAH) and performed everyday. The hCGRP s-r tablet was implanted into the cisterna magna on day 2 in the treated groups. The spastic response of the basilar artery was maximized on day 4 in the non-treated (80.7% of day 1) and the placebo-treated (79.3%) groups. In contrast, the arterial diameters on day 4 were 96.1% and 90.5% of day 1 in the groups implanted with hCGRP 24 micrograms and 153 micrograms s-r tablets, respectively. We also measured the concentration of hCGRP in the cerebrospinal fluid (CSF) following i...Continue Reading

References

Jan 1, 1992·Acta neurochirurgica·A PasqualinJ C Torner
Jun 30, 1992·Annals of the New York Academy of Sciences·I Marshall
Sep 30, 1992·Biochemical and Biophysical Research Communications·Y IchikiT Eto
Nov 1, 1992·Journal of Neurosurgery·R M PlutaE H Oldfield
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L EdvinssonR Uddman
Oct 1, 1990·Neurosurgery·T NakagomiT Sasaki
Apr 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L EdvinssonR Uddman
Dec 1, 1989·Surgical Neurology·A Spallone, F S Pastore
Oct 1, 1988·Journal of Neurosurgery·P PaolettiR Rodriguez y Baena
Feb 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L EdvinssonR Uddman
Jan 3, 1985·Nature·S D BrainI MacIntyre
Apr 1, 1994·Stroke; a Journal of Cerebral Circulation·T ShishidoK Hirakawa
Oct 1, 1993·Journal of Neurosurgery·I YamauraY Maeda
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y TakuwaT Asano
Mar 1, 1963·Brain : a Journal of Neurology·M POLLAY, H DAVSON
Sep 1, 1963·The American Journal of Physiology·K WELCH

❮ Previous
Next ❯

Citations

Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·T KaminumaT Yoshimoto
Oct 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F M Faraci, C G Sobey
Mar 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Adam InstitorisDavid W Busija
Dec 20, 2012·Stroke Research and Treatment·Marcel A KampDaniel Hänggi
Oct 1, 2013·Progress in Neurobiology·Sheng ChenJohn H Zhang
Aug 24, 2010·British Journal of Neurosurgery·Serge MarbacherNeil D Kitchen
May 9, 2014·Journal of the Neurological Sciences·Ana Rodríguez-RodríguezFrancisco Murillo-Cabezas
Nov 9, 2014·Translational Stroke Research·Yuichiro KikkawaTomio Sasaki
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Current Neurovascular Research
Douglas J CookRobert L Macdonald
Acta Pharmacologica Sinica
Ya-ping ZhangDayue Darrel Duan
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Benjamin L ParkerGro Klitgaard Povlsen
© 2021 Meta ULC. All rights reserved