Abstract
Drug efflux-transporters serve as a major barrier to anticancer drugs at the target site. One strategy to enhance the therapeutic efficacy of drugs against cancer is to increase their available concentrations at the target site by suppressing or modulating efflux-transporters. This manuscript deals with the development and evaluation of the particle type drug delivery system made of stearic acid (Solid Lipid Nanoparticle - SLN) and chitosan for the delivery of Phenethyl Isothiocyanate (PEITC), a tumor-suppressive agent, through the pulmonary route. The rationale behind the particle type drug delivery system involves a prior release of the efflux-transporter inhibitors, such as tamoxifen, verapamil HCl or nifedipine, to suppress or modulate the efflux activity of ABC transporters followed by the release of the efflux-transporter substrate, PEITC. The efficacy of Chitosan-SLN Microparticles (CSM) as a carrier for PEITC was evaluated by investigating the release profiles of PEITC loaded in CSM and its cytotoxicity in the presence or absence of the efflux-transporter inhibitors. An initial burst release of the inhibitors, followed by gradual, sustained release of PEITC and subsequent increase in cytotoxicity was observed. This find...Continue Reading
Citations
Mar 30, 2013·Colloids and Surfaces. B, Biointerfaces·Shilei HaoTingwang Guo
Oct 1, 2009·Drug Development and Industrial Pharmacy·M TrottaL Costa
May 5, 2012·Expert Opinion on Drug Delivery·Xia LinXing Tang
Aug 8, 2014·Journal of Drug Targeting·Vimratjeet KaurAmit K Goyal
May 14, 2014·Advanced Drug Delivery Reviews·David CipollaAnthony Hickey
Aug 4, 2009·Drug Discovery Today·Tripta BansalSushama Talegaonkar
Mar 18, 2016·Pharmaceutical Biology·Feng ShiXiming Xu
Mar 31, 2015·Carbohydrate Polymers·Yangchao LuoQin Wang
Jul 27, 2015·Colloids and Surfaces. B, Biointerfaces·Oihane GartziandiaRosa Maria Hernandez
Feb 6, 2015·Carcinogenesis·Alessandra PullieroAlberto Izzotti
Sep 7, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S WeberJ Pardeike
Jun 1, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohammed M MehannaNazik A Elgindy
Jan 30, 2015·Critical Reviews in Food Science and Nutrition·Venkidasamy BaskarShivraj Hariram Nile
Apr 27, 2016·The Journal of Pharmacy and Pharmacology·Hossein Ali EbrahimiMohammad Barzegar Jalali
Nov 12, 2013·Nanoscale Research Letters·Eun-Kyung LimYong-Min Huh
Mar 14, 2018·The Journal of Pharmacy and Pharmacology·Pengli LiChunxia Li
Oct 13, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Ali DabbaghNoorsaadah Abdul Rahman
Oct 12, 2018·Current Drug Delivery·Vieri PiazziniMaria Camilla Bergonzi
Jun 25, 2019·Current Medicinal Chemistry·Bruno Fonseca-SantosMarlus Chorilli
Dec 15, 2020·International Journal of Pharmaceutics·Kaho OgawaHideshi Natsume
Feb 18, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mukta AgrawalAmit Alexander
May 7, 2021·PloS One·Ezequiel R CoscuetaManuela Pintado