Development of chitosan/gelatin hydrogels incorporation of biphasic calcium phosphate nanoparticles for bone tissue engineering

Journal of Biomaterials Science. Polymer Edition
Lei NieShoufeng Yang

Abstract

The chitosan/gelatin hydrogel incorporated with biphasic calcium phosphate nanoparticles (BCP-NPs) as scaffold (CGB) for bone tissue engineering was reported in this article. Such nanocomposite hydrogels were fabricated by using cycled freeze-thawing method, of which physicochemical and biological properties were regulated by adjusting the weight ratio of chitosan/gelatin/BCP-NPs. The needle-like BCP-NPs were dispersed into composites uniformly, and physically cross-linked with chitosan and gelatin, which were identified via Scanning Electron Microscope (SEM) images and Fourier Transform Infrared Spectroscopy (FT-IR) analysis. The porosity, equilibrium swelling ratio, and compressive strength of CGB scaffolds were mainly influenced by the BCP-NPs concentration. In vitro degradation analysis in simulated body fluids (SBF) displayed that CGB scaffolds were degraded up to at least 30 wt% in one month. Also, CCK-8 analysis confirmed that the prepared scaffolds had a good cytocompatibility through in culturing with bone marrow mesenchymal stem cells (BMSCs). Finally, In vivo animal experiments revealed that new bone tissue was observed inside the scaffolds, and gradually increased with increasing months, when implanted CGB scaffolds...Continue Reading

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Citations

Jun 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Caiyun ZhengTingli Lu
May 7, 2020·Polymers·Fatemeh KhosraviMohammad Hossein Nasr-Esfahani
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Feb 19, 2021·Journal of Biomaterials Applications·Aitor Tejo-Otero, Alastair C Ritchie
Feb 9, 2021·Chemistry of Materials : a Publication of the American Chemical Society·Soyon Kim, Min Lee

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Methods Mentioned

BETA
X-ray
infrared spectroscopy
Scanning Electron Microscopy
biopsies
ELISA

Software Mentioned

ImageJ
SPSS

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