PMID: 6981837Jul 1, 1982Paper

Development of chronic lymphocytic leukaemia in a patient with polycythaemia vera

Scandinavian Journal of Haematology
A G PapayannisD Aanagnostou-Keramida

Abstract

A 73-year-old patient who had polycythaemia vera (PV), and who 6 years later developed chronic lymphocytic leukaemia (CCL) is described. 2 years after the appearance of CLL, the polycythaemic phase showed a remission following treatment with phlebotomy and busulfan. CLL did not make all the characteristics of PV disappear: leucocyte alkaline phosphatase and fibrosis of the bone marrow remained increased and the erythrocyte sedimentation rate remained low. The abnormal lymphocytes were B-cells and had the peculiarity that most of their nuclei showed a deep cleft, and some were bilobed. Chromosomal studies of the bone marrow showed the presence of a metacentric chromosome in the C-group, while the karyotype of the peripheral blood was normal. This case is described because of the rarity of the coexistence of these 2 diseases in the same patient.

References

Oct 1, 1978·The Journal of Clinical Investigation·P J FialkowM N Lowenthal
Apr 1, 1977·Postgraduate Medical Journal·D A TabernerB W Otridge
Sep 1, 1974·British Journal of Haematology·A G PapayannisC Gardikas
Jun 1, 1971·Cancer·N J Vianna, L J Essman
Aug 1, 1967·Journal of Cellular Physiology·P C Nowell, L J Cole

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Citations

Sep 4, 2003·Leukemia & Lymphoma·Tadeusz RobakAaron Polliack
Nov 16, 2006·European Journal of Haematology·Kais HusseinHans Kreipe
Nov 1, 1982·Scandinavian Journal of Haematology·N JacobsenA Videbaek
Jan 1, 1989·Blut·T EconomopoulosG Chalevelakis

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