PMID: 9525243Apr 3, 1998Paper

Development of cochlear sensitivity to aminoglycoside antibiotics

The Annals of Otology, Rhinology, and Laryngology
S J O'Leary, D R Moore

Abstract

This study examined the temporal relationship between aminoglycoside ototoxicity and the onset of auditory function in the rat. A single dose of gentamicin sulfate (200 mg/kg) and furosemide (100 mg/kg) was administered on postnatal day 6 (P6), P7, P8, P9, or P10, just before the onset of auditory function. Ototoxicity was assessed by the elevation of auditory brain stem response (ABR) thresholds, recorded once the rats had matured. The ABRs were evoked by acoustic clicks and tone pips. The thresholds of control and P6- and P7-treated animals did not differ significantly from each other. Thresholds of some P8- and all P9-treated animals were elevated. The P10-treated animals were deafened, according to these ABR criteria. These data suggest that the potential for aminoglycoside ototoxicity develops rapidly between P8 and P10, just before the onset of auditory function.

References

May 1, 1979·Archives of Otolaryngology·R E BrummettD L Himes
Dec 1, 1992·Acta Obstetricia Et Gynecologica Scandinavica·B JohanssonB Westin
Feb 1, 1992·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·R Rübsamen
Apr 24, 1992·Brain Research. Developmental Brain Research·D R Moore, J E Hine
Jun 1, 1991·Hearing Research·G P Richardson, I J Russell
Mar 1, 1990·Brain Research. Developmental Brain Research·A L Morey, S Carlile
Jan 1, 1986·Hearing Research·J Schacht
Jan 1, 1987·Anatomy and Embryology·M LenoirR Pujol
Nov 1, 1974·Acta Oto-laryngologica·W Kujpers
Nov 1, 1984·Acta Oto-laryngologica·B A Prieve, J L Yanz
Jan 1, 1983·Archives of Oto-rhino-laryngology·C S Chen, J C Saunders
Sep 1, 1982·Acta Oto-laryngologica·G Dumas, R Charachon
Jan 1, 1981·Audiology : Official Organ of the International Society of Audiology·A UzielM Marot
Nov 1, 1981·Journal of Clinical Pharmacology·R E BrummettD Himes
Sep 1, 1994·Archives of Disease in Childhood. Fetal and Neonatal Edition·P G Hepper, B S Shahidullah
Jan 1, 1994·Toxicologic Pathology·J D FikesT Yoshioka
Mar 1, 1994·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·R J SalviL Chen
Dec 1, 1995·Hearing Research·R K Shepherd, R L Martin
Aug 1, 1963·The Journal of Experimental Zoology·R S SCHMIDT, C FERNANDEZ

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Citations

Sep 18, 2007·The European Journal of Neuroscience·Patricia A HurleyRobert K Shepherd
Apr 29, 1998·The Annals of Otology, Rhinology, and Laryngology·D R MooreS J O'Leary
May 26, 2004·Hearing Research·Jennifer L HeydtMarc D Coltrera

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