PMID: 8605571Mar 1, 1996Paper

Development of colonic and pancreatic endocrine tumours in mice expressing a glucagon-SV40 T antigen transgene

Virchows Archiv : an International Journal of Pathology
S L AsaD J Drucker

Abstract

We report the histological, immunohistochemical and ultrastructural changes in mice containing a chimeric glucagon-simian virus 40 T antigen (SV40Tag) gene. Transgene expression was detected in endocrine cells of pancreas, small and large intestine. Hyperplasia of glucagon-containing cells developed in pancreas and large bowel by gestational day 19. In large bowel, hyperplastic cells increased in number postnatally and invasive carcinomas were identified at 4 weeks; several animals had lymph node metastases. In contrast, no pathology was detected in the small bowel in any of the transgenic mice. Colonic tumours expressed SV40Tag, proglucagon-derived peptides and peptide YY (PYY); scattered cells contained cholecystokinin or glycoprotein hormone alpha-subunit. Somatostatin or serotonin was also detected in some tumours. By electron microscopy, the colonic tumours retained features of endocrine differentiation, but secretory granules were smaller than those of non-tumorous intestinal glucagon-producing L cells. In postnatal pancreas, atypical cells containing SV40Tag and glucagon were initially clustered at the periphery of islets; this atypical hyperplasia progressed to neoplasia by 11-12 weeks. Some neoplastic pancreatic cells ...Continue Reading

Citations

Nov 12, 2010·The Lancet Oncology·Danielle CollinsDesmond C Winter
Aug 12, 2015·Molecular and Cellular Endocrinology·Run Yu
Apr 4, 2006·Developmental Biology·Wataru NishimuraArun Sharma
May 22, 2004·Annals of the New York Academy of Sciences·Babette Simon, Nikolaus Lubomierski
Sep 26, 2003·Psychosomatic Medicine·Caroline P CarneyBradley N Doebbeling
Dec 26, 2001·Oncogene·M T Sáenz-RoblesJ M Pipas
Jun 17, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mark KiddRoswitha Pfragner
Jan 1, 2009·American Journal of Physiology. Endocrinology and Metabolism·Safina Ali, Daniel J Drucker
Aug 26, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Denise D BelshamMargaret M Koletar
Oct 12, 2007·Physiological Reviews·Jens Juul Holst
Mar 29, 2018·Disease Models & Mechanisms·Kenta KawasakiToshiro Sato
Oct 12, 1999·The American Journal of Physiology·M NianD Irwin

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