Abstract
Captopril granules of controlled release with different polymers as ethylcellulose, ethyl/methylcellulose, and immediate release with polyvinylpyrrolidone (PVP) were developed by fluid bed dryer technique. The formulations were analyzed by scanning electron microscopy, X-ray powder diffraction, and dissolution profiles. To compare the formulations an in vivo setting rat blood pressure assay was performed, using angiotensin I as a vasoconstrictor agent. The scanning electron microscopy of granules showed differences in morphology, and X-ray powder diffraction technique presented some modification in crystalline structure of captopril in granules coated with PVP and ethyl/methylcellulose. The dissolution profile of granules coated with ethylcellulose showed a median time release of 4 hr whereas for granules coated with ethyl/methylcellulose, this time was 3.5 hr. The blockage of angiotensin I-induced hypertensive effect lasted 8 hr in granules coated with PVP and of more than 12 hr in the granules coated with ethylcellulose and ethyl/methylcellulose.
References
May 1, 1992·Pharmaceutical Research·I R WildingJ Brennan
Apr 1, 1988·Journal of Microencapsulation·J Singh, D H Robinson
Dec 1, 1972·The Journal of Pharmacy and Pharmacology·F Langenbucher
Oct 1, 1969·Journal of Pharmaceutical Sciences·J G Wagner
Jan 1, 1983·Drugs·J A RomankiewiczG S Avery
Jan 1, 1982·Medicinal Research Reviews·E W Petrillo, M A Ondetti
Mar 14, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·M E FranklinW D Hooper
Mar 21, 1998·Journal of Pharmaceutical and Biomedical Analysis·R J MarkovichJ Rosen
Jan 7, 1999·Drug Development and Industrial Pharmacy·C T Rhodes, S C Porter
Jul 29, 2000·Drug Development and Industrial Pharmacy·A O Nur, J S Zhang
Aug 10, 2000·Pharmaceutical Development and Technology·M Efentakis, M Vlachou
Sep 1, 2000·International Journal of Pharmaceutics·D L Munday, P J Cox
Apr 12, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·P Costa, J M Sousa Lobo
Dec 1, 1963·Journal of Pharmaceutical Sciences·T HIGUCHI
Apr 15, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sunil A Agnihotri, Tejraj M Aminabhavi
May 19, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alan RoyceUday Shah
Jan 18, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jun-ichi JinnoToshikiro Kimura
Jul 4, 2006·International Journal of Pharmaceutics·Troy PurvisRobert O Williams
Aug 22, 2006·International Journal of Pharmaceutics·P W S HengE S K Tang
Citations
Jun 6, 2012·TheScientificWorldJournal·Jessica Bitencourt Emilio MendesPaulo Vitor Farago
Mar 10, 2009·Drug Delivery·Harikrishna BoyapallyDionysios Douroumis
Apr 5, 2020·Pest Management Science·Anqi WangHaixin Cui