PMID: 16618974Apr 19, 2006Paper

Development of cookie test for the simultaneous determination of glucose intolerance, hyperinsulinemia, insulin resistance and postprandial dyslipidemia

Endocrine Journal
Yutaka HaranoTakamitsu Nakano

Abstract

A new cookie test was developed for the simultaneous evaluation of multiple risk factors such as glucose intolerance, hyperinsulinemia, insulin resistance and postprandial dyslipidemia. The cookie consisting of 75 g carbohydrate and 25 g fat is ingested and the blood samples are obtained at 0, 1 and 2 hours later. When the two carbohydrate sources, liquid glucose and test cookie, were compared as a glucose load within 3 months, the 2 hr plasma glucose levels were not statistically different, proposing the use of the same criteria at 2 hour glucose level for the diagnosis of diabetes and impaired glucose tolerance (IGT) in subjects without exocrine pancreatic dysfunction. In addition, hyperinsulinemia, insulin resistance (AUC insulin, and/or AUC insulin X AUC glucose), and postprandial hyperlipidemia (DeltaTG, Triglyceride; DeltaRLP, remnant like particles) have been simultaneously uncovered. Reactive hypoglycemia with adverse epigastric discomfort was observed in 26.3% of the control subjects with liquid glucose, while it was observed in only 1 case (5.3%) without any symptom with cookie tests. In fact, one reactive hypoglycemia out of 5 with liquid glucose turned out to be IGT with cookie test. In 64 subjects with lifestyle-re...Continue Reading

References

Jun 1, 1977·The American Journal of Clinical Nutrition·Y HaranoM Hoshi
Aug 26, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·A TanakaF Numano
Feb 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·B G KaramanosD P Roussi-Penesi
Mar 2, 2002·Journal of Diabetes and Its Complications·Yutaka HaranoItaru Takamizawa
Jun 11, 2003·Archives of Internal Medicine·John E Gerich
Jan 14, 2004·Journal of Atherosclerosis and Thrombosis·Masahiko IgarashiTakeo Kato
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Franco Maria MaggiAlberico Luigi Catapano

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Citations

Jul 20, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Iwona WybranskaAldona Dembinska-Kiec
Feb 1, 2007·Neuropsychiatric Disease and Treatment·Takahiko Nagamine
Sep 13, 2013·Nutrients·Hashim A PeriyalilLisa G Wood
Jan 28, 2014·Cardiovascular Diabetology·Jean-Charles FruchartUNKNOWN Residual Risk Reduction Initiative (R3i)
Jun 5, 2014·Journal of Clinical Biochemistry and Nutrition·Masae SakumaHidekazu Arai
Dec 3, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Toru MiyoshiHiroshi Ito
Jan 9, 2016·Journal of cardiology·Kazufumi NakamuraHiroshi Ito
Oct 7, 2015·Journal of Nutritional Science and Vitaminology·Sayuki HashimotoMichitaka Naito
Jul 5, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Norihiro FurusyoJun Hayashi
Feb 2, 2013·Diabetes Research and Clinical Practice·Tetsuji TsunodaIchiro Michishita
Dec 3, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Nobuyoshi IshiyamaKatsuyuki Nakajima
Dec 18, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Katsuyuki NakajimaMasami Murakami
May 5, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ruth FreemanElla Rosenbloom
Mar 2, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Katsuyuki Nakajima, Akira Tanaka
Aug 30, 2017·Clinical and Experimental Nephrology·Makoto TsujitaYoshihiko Watarai
Jun 22, 2012·International Journal of Food Sciences and Nutrition·Yoshihisa UritaMotonobu Sugimoto
Dec 7, 2017·The American Journal of the Medical Sciences·Wandee ChanprasertpinyoChutintorn Sriphrapradang
Jan 9, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·Katsuyuki Nakajima, Akira Tanaka
Sep 18, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Keita HoritaniIchiro Shiojima
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