Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring

Biomaterials
M L MancaM Manconi

Abstract

In the present work new highly biocompatible nanovesicles were developed using polyanion sodium hyaluronate to form polymer immobilized vesicles, so called hyalurosomes. Curcumin, at high concentration was loaded into hyalurosomes and physico-chemical properties and in vitro/in vivo performances of the formulations were compared to those of liposomes having the same lipid and drug content. Vesicles were prepared by direct addition of dispersion containing the polysaccharide sodium hyaluronate and the polyphenol curcumin to a commercial mixture of soy phospholipids, thus avoiding the use of organic solvents. An extensive study was carried out on the physico-chemical features and properties of curcumin-loaded hyalurosomes and liposomes. Cryogenic transmission electron microscopy and small-angle X-ray scattering showed that vesicles were spherical, uni- or oligolamellar and small in size (112-220 nm). The in vitro percutaneous curcumin delivery studies on intact skin showed an improved ability of hyalurosomes to favour a fast drug deposition in the whole skin. Hyalurosomes as well as liposomes were biocompatible, protected in vitro human keratinocytes from oxidative stress damages and promoted tissue remodelling through cellular p...Continue Reading

References

Aug 1, 1996·International Journal of Dermatology·W Manuskiatti, H I Maibach
May 7, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·W Y Chen, G Abatangelo
Nov 23, 2000·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·G PabstP Laggner
May 5, 2001·International Journal of Pharmaceutics·Z PavelićR Schubert
Jan 24, 2004·Biomaterials·D GopinathR Jayakumar
Oct 16, 2004·The Journal of Pharmacy and Pharmacology·Carmelo PugliaFrancesco Bonina
Apr 29, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·M B Brown, S A Jones
May 24, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sun Jin KimYoung Phil Lee
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
Mar 18, 2008·Journal of Colloid and Interface Science·Mohamed YoussryCarmen Morán
Mar 29, 2008·Antioxidants & Redox Signaling·Alexios S Strimpakos, Ricky A Sharma
May 13, 2008·International Journal of Pharmaceutics·Zrinka AbramovićJulijana Kristl
Jul 3, 2009·Expert Opinion on Drug Delivery·Chiara Sinico, Anna Maria Fadda
Aug 19, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shailja TiwariSuresh P Vyas
Mar 11, 2010·Current Medicinal Chemistry·G Bar-SelaM Schaffer
Dec 21, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Maria ManconiAnna Maria Fadda
Feb 10, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Rita MuzzalupoNevio Picci
Jun 16, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Donatella PaolinoMassimo Fresta
Aug 3, 2013·Colloids and Surfaces. B, Biointerfaces·Maria Letizia MancaAnna Maria Fadda
Aug 6, 2013·International Journal of Pharmaceutics·Maria Letizia MancaAnna Maria Fadda
Feb 18, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yosra S R ElnaggarOssama Y Abdallah
Apr 1, 2014·Colloids and Surfaces. B, Biointerfaces·Maria Letizia MancaMaria Manconi
Sep 23, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Aimee E KrauszAdam J Friedman
Dec 3, 2014·Colloids and Surfaces. B, Biointerfaces·Maria Letizia MancaMaria Manconi

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Citations

Feb 18, 2016·Journal of Materials Science. Materials in Medicine·Ines CastangiaMaria Manconi
Mar 30, 2016·Colloids and Surfaces. B, Biointerfaces·Virginia MelisMaria Manconi
Apr 17, 2016·International Journal of Pharmaceutics·Maria ManconiAnna Maria Fadda
Jun 29, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ana Catalan-LatorreMaria Manconi
Jul 5, 2016·International Journal of Pharmaceutics·Silvia Mir-PalomoAmparo Ruiz Saurí
Jul 29, 2017·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Alka Lohani, Anurag Verma
Jul 30, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Mrinalini SharmaBeena Jain
Sep 27, 2018·Critical Reviews in Analytical Chemistry·Renata Carolina AlvesMarlus Chorilli
Sep 14, 2018·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Maryam RameshkMehrnaz Mehrabani
May 18, 2019·Drug Development and Industrial Pharmacy·S Bernal-ChávezA Ganem-Rondero
Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Angela AbruzzoTeresa Cerchiara
Jul 24, 2020·Nanomedicine·Maria ManconiAnna Maria Fadda
Oct 1, 2020·Journal of Drug Targeting·Zaynab Sadeghi-GhadiAli Nokhodchi
Aug 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raghavendhar R Kotha, Devanand L Luthria
Jan 23, 2020·Journal of Materials Science. Materials in Medicine·Virginia CampaniGiuseppe De Rosa
May 8, 2018·International Journal of Molecular Sciences·Elisabet Martí Coma-CrosXavier Fernàndez-Busquets
Apr 10, 2019·IET Nanobiotechnology·Yong-Tai ZhangNian-Ping Feng
Dec 21, 2016·Macromolecular Bioscience·Julia KoehlerFerdinand P Brandl
May 21, 2019·Journal of Microencapsulation·Zaynab Sadeghi Ghadi, Pedram Ebrahimnejad
Jul 4, 2020·Nature Reviews. Materials·C L StablerB G Keselowsky
Nov 2, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fernando Pereira BeserraChristopher John Jackson
Dec 7, 2020·International Journal of Biological Macromolecules·Xingwei WangXiaoming Zhang
Sep 23, 2019·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Selenia TernulloNataša Škalko-Basnet

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