Development of de novo major involvement during follow-up in Behçet's syndrome

Clinical Rheumatology
Rosaria TalaricoMarta Mosca

Abstract

The primary aim of the study was to evaluate the incidence of de novo major involvement during follow-up in a cohort of patients with Behçet's syndrome (BS); the secondary aim was to analyse the epidemiological profile and the long-term outcome of those patients who developed new major involvement. Among our cohort of 120 BS patients, we evaluated all subjects who had no major organ involvement during the early years of their disease; specifically, at disease onset, the 52% of the cohort presented a prevalent mucocutaneous involvement. The primary outcomes were represented by the following: Hatemi et al. (Rheum Dis Clin North Am 39(2):245-61, 2013) the incidence of de novo major involvement during the follow-up and Hatemi et al. (Clin Exp Rheumatol 32(4 Suppl 84):S112-22, 2014) the use of immunosuppressive drugs during the follow-up. We have defined the development of de novo major involvement during the follow-up as the occurrence of severe ocular, vascular or CNS involvement after a latency period from the diagnosis of at least 3 years. Among 62 patients characterized by a mild onset of disease, we observed that after at least 3 years from the diagnosis, 21 BS patients (34%) still developed serious morbidities. Specifically, ...Continue Reading

References

May 21, 2003·International Journal of Dermatology·Umit TursenAyse Boyvat
Sep 15, 2004·American Journal of Ophthalmology·Ilknur Tugal-TutkunMeri Urgancioglu
Aug 23, 2007·The British Journal of Dermatology·E AlpsoyA Akman
Apr 9, 2010·International Journal of Rheumatic Diseases·Fereydoun DavatchiAlireza Faridar
Nov 22, 2011·Best Practice & Research. Clinical Rheumatology·Gulen Hatemi, Hasan Yazici
Jun 8, 2012·Clinical Reviews in Allergy & Immunology·H YaziciE Seyahi
Apr 20, 2013·Rheumatic Diseases Clinics of North America·Gulen HatemiHasan Yazici
Dec 7, 2013·Clinical Rheumatology·Luca CantariniRolando Cimaz
Mar 13, 2014·Current Opinion in Rheumatology·Yesim OzgulerHasan Yazici
Mar 25, 2014·Clinical Rheumatology·Antonio VitaleLuca Cantarini
Apr 17, 2014·Clinical Rheumatology·Fatma Alibaz-OnerHaner Direskeneli
Jul 26, 2014·Mediators of Inflammation·Francesco CasoLuca Cantarini

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Citations

Oct 9, 2019·Rheumatology International·Rosaria TalaricoMarta Mosca

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