PMID: 19938329Nov 26, 2009Paper

Development of decision tools to assess migration from plastic materials in contact with food

Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
G GilletS Desobry

Abstract

Testing the specific migration limits of all substances intentionally added to polymer material according to European Union (EU) regulation is a time-consuming and expensive task. Although mathematical modeling offers an interesting alternative, it can significantly overestimate the migration in situations which are strongly conservative due to significant uncertainty in transport properties. In addition, its application is of little use for end-users or enforcement laboratories, which do not have access to the formulation. This paper revises the paradigm of migration modeling by combining modeling with deformulation experiments and iterative modeling in the framework of decision theory. The complete approach is illustrated for polyolefins in contact with 50% ethanol for eight typical migrants, including hindered phenolic antioxidants and low molecular weight surrogates. Results from a French ACTIA project on the identification of formulation fingerprints and on the prediction of partition coefficients with alcoholic and aqueous stimulants is described. When the true migration was close but still lower than the limit of concern, the proposed compact decision tree, including up to four sources of uncertainty, showed that the cha...Continue Reading

References

Oct 18, 2005·Food Additives and Contaminants·J H PetersenB Fabech
Dec 7, 2005·Journal of Chromatography. a·Alvaro Garrido-López, María Teresa Tena
Feb 2, 2006·Food Additives and Contaminants·Patrice DoleCostas Papaspyrides
Apr 25, 2007·Food Additives and Contaminants·T RothenbacherD Fügel
May 26, 2007·Rapid Communications in Mass Spectrometry : RCM·Renzo BagnatiEnrico Davoli
Jul 9, 2008·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·R Franz, F Welle
Sep 2, 2009·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Françoise A ValentiniPierre P Nelson

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Citations

Oct 30, 2016·Critical Reviews in Food Science and Nutrition·Xiaoyi Fang, Olivier Vitrac
Jun 15, 2017·Critical Reviews in Food Science and Nutrition·Gavriil GavriilFrank A Coutelieris
Sep 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Phuong-Mai NguyenOlivier Vitrac

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